Renal perfusion evaluation with contrast-enhanced ultrasonography
Renal perfusion evaluation with contrast-enhanced ultrasonography
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DOI：
10.1093/ndt/gfr345
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发表时间：
2012-02-01
影响因子：
6.1
通讯作者：
Vogt, Bruno
中科院分区：
文献类型：
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作者：
Schneider, Antoine G.;Hofmann, Lucie;Vogt, Bruno
超声造影（CEUS）是一种新型的成像技术，安全，适用于床旁。最近的发展似乎使CEUS定量器官灌注。我们进行了一项探索性研究，以确定CEUS检测肾脏灌注变化的能力，并将其与有效的肾血浆flow.CEUS与破坏再填充序列进行了研究，在10名健康受试者，在基线和低（1 ng/kg/min）和高剂量（3 ng/kg/min）的血管紧张素II（AngII）和口服卡托普利（50 mg）后1小时输注。灌注指数（PI）与对氨基马尿酸（PAH）清除率测定的有效肾血浆流量（ERPF）比较，PI中位数从188.6（基线）至100.4，使用低剂量AngII（-47%; P < 0.02）和高剂量AngII（-65%; P < 0.01）增加到66.1，但用Captopril（+35%; P > 0.2）增加到254.7。这些变化与ERPF观察到的变化相似，ERPF从中位数672.1 mL/min（基线）至572.3（低剂量AngII，-15%，P < 0.05）和427.2（高剂量AngII，-36%，P < 0.001），最终697.1（巯甲丙脯酸，+4%，本研究表明，CEUS能够检测到血管紧张素II灌注和/或血管紧张素II灌注引起的人肾皮质微循环的变化。或给予卡托普利。灌注指数的变化与通过PAH清除获得的ERPF中的变化平行。
Contrast-enhanced ultrasonography (CEUS) is a novel imaging technique that is safe and applicable on the bedside. Recent developments seem to enable CEUS to quantify organ perfusion. We performed an exploratory study to determine the ability of CEUS to detect changes in renal perfusion and to correlate them with effective renal plasma flow.CEUS with destruction-refilling sequences was studied in 10 healthy subjects, at baseline and during infusion of angiotensin II (AngII) at low (1 ng/kg/min) and high dose (3 ng/kg/min) and 1 h after oral captopril (50 mg). Perfusion index (PI) was obtained and compared with the effective renal plasma flow (ERPF) obtained by parallel para-aminohippurate (PAH) clearance.Median PI decreased from 188.6 (baseline) to 100.4 with low-dose AngII (-47%; P < 0.02) and to 66.1 with high-dose AngII (-65%; P < 0.01) but increased to 254.7 with captopril (+35%; P > 0.2). These changes parallelled those observed with ERPF, which changed from a median of 672.1 mL/min (baseline) to 572.3 (low-dose AngII, -15%, P < 0.05) and to 427.2 (high-dose AngII, -36%, P < 0.001) and finally 697.1 (captopril, +4%, P < 0.02).This study demonstrates that CEUS is able to detect changes in human renal cortical microcirculation as induced by AngII infusion and/or captopril administration. The changes in perfusion indices parallel those in ERPF as obtained by PAH clearance.