Antibody response to first and second dose of BNT162b2 in a cohort of characterized healthcare workers.
Antibody response to first and second dose of BNT162b2 in a cohort of characterized healthcare workers.
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DOI：
10.1016/j.cca.2021.04.006
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Plebani M
中科院分区：
文献类型：
--
作者：
Padoan A;Dall'Olmo L;Rocca FD;Barbaro F;Cosma C;Basso D;Cattelan A;Cianci V;Plebani M
疫苗诱导的群体免疫是控制2019冠状病毒病（COVID-19）的关键全球策略。几种COVID-19疫苗的快速实施和可用性现在是全球卫生保健的优先事项，但需要更多关于单剂量和双剂量疫苗的体液反应的信息。帕多瓦大学医院的163名保健工作者，要求接受BNT 162 b2疫苗完整接种活动的受试者在首次接种后12（t12）和28（t28）天采集血清样本，以允许使用针对刺突（S）蛋白和受体结合结构域（RBD）的荧光测定法测量SARS-CoV-2抗体（Ab）。病毒，分别。在t12时，未感染和既往自然感染的受试者存在显著差异，这些受试者的特异性抗体值较高，而t12和t28之间未发现显著差异。在男性和女性之间未发现统计学显著差异，而在t12时在60岁以上的受试者中观察到较低的Ab水平，但在t28时未观察到。我们的研究证实了在t12时未感染和既往自然感染受试者之间观察到的疫苗应答差异，但不会持续更长时间。性别和年龄的影响值得进一步研究，即使与年龄的关系似乎特别重要。
Vaccine-induced population immunity is a key global strategy to control coronavirus disease 2019 (COVID-19). The rapid implementation and availability of several COVID-19 vaccines is now a global health-care priority but more information about humoral responses to single- and double-dose vaccine is needed. 163 health care workers (HCW) of the Padua University Hospitals, who underwent a complete vaccination campaign with BNT162b2 vaccine were asked to collect serum samples at 12 (t12) and 28 (t28) days after the first inoculum to allow the measurement of SARS-CoV-2 Antibodies (Ab) using chemiluminescent assays against the spike (S) protein and the Receptor Binding Domain (RBD) of the virus, respectively. Significant differences were found at t12 for infection-naïve and subjects with previous-natural infection who present higher values of specific antibodies, while no significant differences have been found between t12 and t28. No statistically significant difference was found between male and female, while lower Ab levels have been observed in subjects older than 60 years at t12 but not at t28. Our study confirms observed differences in vaccine responses between infection-naïve and subjects with previous natural infection at t12 but not for a longer time. The influence of sex and age deserves further studies, even if the relationship with age seems particularly significant.
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BNT162B2 mRNA COVID-19疫苗的安全性和功效。
DOI：
10.1056/nejmoa2034577
发表时间：
2020-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Polack FP;Thomas SJ;Kitchin N;Absalon J;Gurtman A;Lockhart S;Perez JL;Pérez Marc G;Moreira ED;Zerbini C;Bailey R;Swanson KA;Roychoudhury S;Koury K;Li P;Kalina WV;Cooper D;Frenck RW Jr;Hammitt LL;Türeci Ö;Nell H;Schaefer A;Ünal S;Tresnan DB;Mather S;Dormitzer PR;Şahin U;Jansen KU;Gruber WC;C4591001 Clinical Trial Group
通讯作者：
C4591001 Clinical Trial Group
影响因子：
82.9
作者：
Amanat F;Stadlbauer D;Strohmeier S;Nguyen THO;Chromikova V;McMahon M;Jiang K;Arunkumar GA;Jurczyszak D;Polanco J;Bermudez-Gonzalez M;Kleiner G;Aydillo T;Miorin L;Fierer DS;Lugo LA;Kojic EM;Stoever J;Liu STH;Cunningham-Rundles C;Felgner PL;Moran T;García-Sastre A;Caplivski D;Cheng AC;Kedzierska K;Vapalahti O;Hepojoki JM;Simon V;Krammer F
通讯作者：
Krammer F
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
影响因子：
5
作者：
Plebani, Mario;Padoan, Andrea;Sciacovelli, Laura
通讯作者：
Sciacovelli, Laura
影响因子：
3.9
作者：
Schaffner A;Risch L;Aeschbacher S;Risch C;Weber MC;Thiel SL;Jüngert K;Pichler M;Grossmann K;Wohlwend N;Lung T;Hillmann D;Bigler S;Bodmer T;Imperiali M;Renz H;Kohler P;Vernazza P;Kahlert CR;Twerenbold R;Paprotny M;Conen D;Risch M
通讯作者：
Risch M