Relationship between Immunophenotype and Clinicopathological Findings for Superficial Nonampullary Duodenal Epithelial Tumor
Relationship between Immunophenotype and Clinicopathological Findings for Superficial Nonampullary Duodenal Epithelial Tumor
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DOI：
10.1159/000514812
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发表时间：
2021-04-01
期刊：
影响因子：
3.2
通讯作者：
Kataoka, Hiromi
中科院分区：
文献类型：
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作者：
Fukusada, Shigeki;Shimura, Takaya;Kataoka, Hiromi
简介：浅表性非壶腹性十二指肠上皮肿瘤（SNADETs）的自然历史和预后仍不确定。我们阐明了免疫表型与临床病理特征之间的关系。材料与方法：98例SNADETs根据免疫组化结果分为3组：胃表型（G型）、胃肠道表型（GI型）和肠道表型（I型）。细胞异常增生分为低级别异常增生和高级别异常增生/腺癌（>= HGD）。白色不透明物质（WOS）沉积根据内镜表现分为弥漫性WOS、部分WOS和无WOS。结果98例SNADETs中，G型病变4例（4.1%），GI型病变32例（32.7%），I型病变62例（63.2%）。G型snadet均位于包括球部在内的乳头的口腔一侧，且球部病变在G型中的发生率明显高于GI型和I型（p = 0.004）。最常见的WOS类型为G型无WOS (4/4, 100%)， GI型部分WOS (19/32, 59.4%)， I型弥漫性WOS (34/62, 54.8%) (p < 0.001)，肠道特征丧失与WOS缺乏显著相关。伴有部分或无WOS的GI/ i型SNADETs和g型SNADETs与>= HGD相关。cd10阴性组>= HGD病变发生率明显高于cd10阳性组（57.1 vs. 19.8%, p = 0.043）。结论：病理肠道特征与WOS存在相关，CD10缺失与SNADETs的恶性潜能相关。
Introduction: The natural history and prognosis of superficial nonampullary duodenal epithelial tumors (SNADETs) remain uncertain. We elucidated the relationship between immunophenotype and clinicopathological features. Materials and Methods: A total of 98 SNADETs were divided into 3 groups according to immunohistochemical findings: gastric phenotype (G type), gastrointestinal phenotype (GI type), and intestinal phenotype (I type). Cellular dysplasia was divided into low-grade dysplasia and high-grade dysplasia/adenocarcinoma (>= HGD). White opaque substance (WOS) deposition was categorized into diffuse WOS, partial WOS, and no WOS, based on endoscopic findings. Results: Of the 98 SNADETs, 4 lesions (4.1%) were G type, 32 lesions (32.7%) were GI type, and 62 lesions (63.2%) were I type. All G-type SNADETs were located in the oral side of the papilla including the bulb, and the rate of bulbar lesions was significantly higher in the G type than in the GI and I types (p = 0.004). The most frequent type of WOS was no WOS (4/4, 100%) for G type, partial WOS (19/32, 59.4%) for GI type, and diffuse WOS (34/62, 54.8%) for I type (p < 0.001), and loss of intestinal character was significantly correlated with WOS deficiency. GI/I-type SNADETs with partial or no WOS and G-type SNADETs were associated with >= HGD. Additionally, the frequency of >= HGD lesion was significantly higher in the CD10-negative group than in the CD10-positive group (57.1 vs. 19.8%, p = 0.043). Conclusion: Pathological intestinal character was correlated with the presence of WOS, and CD10 loss was associated with malignant potential of SNADETs.