Altered calcium homeostasis is correlated with abnormalities of fasting serum glucose, insulin resistance, and β-cell function in the Newfoundland population
Altered calcium homeostasis is correlated with abnormalities of fasting serum glucose, insulin resistance, and β-cell function in the Newfoundland population
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DOI：
10.2337/diabetes.54.11.3336
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发表时间：
2005-11-01
期刊：
影响因子：
7.7
通讯作者：
Zhang, HW
中科院分区：
文献类型：
--
作者：
Sun, G;Vasdev, S;Zhang, HW
细胞外钙离子浓度的改变可能通过多种途径参与葡萄糖代谢。本研究旨在调查加拿大纽芬兰和拉布拉多省1,182名健康受试者血清总钙与1）空腹血糖、2）胰岛素、3）胰岛素抵抗和4）P细胞功能之间的关系。所有变量均进行log（10）转换，并在分析前调整混杂因素，包括年龄、躯干脂肪百分比、血清磷、镁、25-OH维生素D和甲状旁腺激素。葡萄糖和胰岛素抵抗与钙之间的显着正相关关系，发现在两种性别，而P细胞功能和钙之间的负相关关系，发现只有在妇女。在无药物治疗的女性和男性以及绝经前后的女性中也发现了类似的结果。钙水平低的受试者的葡萄糖浓度最低，胰岛素抵抗最轻，而钙水平高的受试者的葡萄糖浓度最高，女性的胰岛素抵抗最低，但男性则不然。这种关系仍然保持钙25-羟基维生素D和甲状旁腺激素调整后。我们的结果表明，血清钙稳态的改变与血糖水平、胰岛素抵抗和P细胞功能异常显着相关。
Alteration of extracellular calcium concentration may be involved in glucose metabolism in a number of pathways. The present study was designed to investigate the relationship between total serum calcium and 1) fasting serum glucose, 2) insulin, 3) insulin resistance, and 4) P-cell function in 1,182 healthy subjects from the province of Newfoundland and Labrador, Canada. All variables were log(10) transformed, and confounding factors including age, trunk fat percentage, serum phosphorus, magnesium, 25-OH vitamin D, and parathyroid hormone were adjusted before analyses. Significant positive correlations between glucose and insulin resistance with calcium were found in both sexes, whereas an inverse correlation between P-cell function and calcium was found only in women. Similar results were found in medication-free women and men, as well as in pre- and postmenopausal women. Subjects with low calcium levels had the lowest concentration of glucose and the least insulin resistance, whereas subjects with high calcium levels had the highest concentration of glucose and insulin resistance in women but not in men. This relationship remained after calcium was adjusted for 25-OH vitamin D and parathyroid hormone. Our results suggest that alteration of serum calcium homeostasis is significantly correlated with the abnormality of glucose level, insulin resistance, and P-cell function.