Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice.
Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice.
复制标题
DOI：
10.3389/fimmu.2017.00467
复制
发表时间：
2017
影响因子：
7.3
通讯作者：
Colucci F
中科院分区：
文献类型：
--
作者：
Gaynor LM;Colucci F
近年来，我们对自然杀伤 (NK) 细胞的发育和功能的了解取得了显着进展。然而，子宫 NK (uNK) 细胞究竟如何发育和发挥作用仍不清楚。为了帮助开始研究组织 NK 细胞的研究人员，我们在这篇综述中总结了我们目前对 uNK 细胞的发育和功能的了解，以及尚未阐明的内容。我们在先天淋巴细胞生物学的更广泛背景下并参考外周 NK 细胞，比较和对比了人类和小鼠 uNK 细胞的生物学。我们还回顾了 uNK 细胞如何调节人类和小鼠妊娠中的滋养层侵袭和子宫螺旋动脉重塑。
Our understanding of development and function of natural killer (NK) cells has progressed significantly in recent years. However, exactly how uterine NK (uNK) cells develop and function is still unclear. To help investigators that are beginning to study tissue NK cells, we summarize in this review our current knowledge of the development and function of uNK cells, and what is yet to be elucidated. We compare and contrast the biology of human and mouse uNK cells in the broader context of the biology of innate lymphoid cells and with reference to peripheral NK cells. We also review how uNK cells may regulate trophoblast invasion and uterine spiral arterial remodeling in human and murine pregnancy.