Copper and manganese co-mediated cascade aza-Michael addition/cyclization and azidation of 1,3-enynes: regioselective synthesis of fully substituted azido pyrroles
Copper and manganese co-mediated cascade aza-Michael addition/cyclization and azidation of 1,3-enynes: regioselective synthesis of fully substituted azido pyrroles
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铜和锰共介导的级联氮杂迈克尔加成/环化和1,3-烯炔的叠氮化：完全取代的叠氮吡咯的区域选择性合成
DOI：
10.1039/d0ob01927e
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发表时间：
2020-11-21
影响因子：
3.2
通讯作者：
Peng, Yiyuan
中科院分区：
文献类型：
--
作者：
Ge, Junying;Ding, Qiuping;Peng, Yiyuan
研究了Cu和Mn共同介导的1，3-烯炔与胺和叠氮三甲基硅（TMSN 3）的有氧氧化环化和叠氮化反应，合成了全取代叠氮吡咯。该三组分反应具有区域选择性高、底物范围广、反应条件温和的特点。提出了这种转变的初步机制。
An efficient Cu and Mn co-mediated aerobic oxidative cyclization and azidation reaction of 1,3-enynes with amines and trimethylsilyl azide (TMSN3) for the synthesis of fully substituted azido pyrroles has been developed. The three-component reaction has the characteristics of high regioselectivity, wide substrate scope, and mild reaction conditions. A preliminary mechanism for this transformation is proposed.