Enantioselective Synthesis of Planar Chiral Ferrocenes via Palladium-Catalyzed Direct Coupling with Arylboronic Acids
Enantioselective Synthesis of Planar Chiral Ferrocenes via Palladium-Catalyzed Direct Coupling with Arylboronic Acids
复制标题
钯催化与芳基硼酸直接偶联对映选择性合成平面手性二茂铁
DOI：
10.1021/ja311082u
复制
发表时间：
2013-01-09
影响因子：
15
通讯作者：
You, Shu-Li
中科院分区：
文献类型：
--
作者：
Gao, De-Wei;Shi, Yan-Chao;You, Shu-Li
实现了Pd（II）催化的氨基甲基二茂铁衍生物与硼酸的不对称直接偶联。以Boc-L-Val-OH为配体，在温和条件下合成了平面手性二茂铁，产率14-81%，ee值高达99%。
Enantioselective Pd(II)-catalyzed direct coupling of aminomethylferrocene derivatives with boronic acids was realized. With commercially available Boc-L-Val-OH as a ligand, planar-chiral ferrocenes could be synthesized in yields of 14-81% with up to 99% ee under mild conditions.