Epileptiform bursts elicited in CA3 hippocampal neurons by a variety of convulsants are not blocked by N-methyl-d-aspartate antagonists
Epileptiform bursts elicited in CA3 hippocampal neurons by a variety of convulsants are not blocked by N-methyl-d-aspartate antagonists
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N-甲基-d-天冬氨酸拮抗剂不能阻断多种惊厥因素在 CA3 海马神经元中引起的癫痫样爆发
DOI：
10.1016/0006-8993(88)90642-7
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发表时间：
1988
期刊：
影响因子：
2.9
通讯作者：
Y. Ben
中科院分区：
文献类型：
--
作者：
R. Neuman;E. Cherubini;Y. Ben
利用体外培养的CA3海马神经元细胞内和细胞外记录，研究了几种N-甲基-d-天冬氨酸(N-甲基-d-天冬氨酸)受体拮抗剂对NMDA和不作用于NMDA受体的惊厥药所致癫痫样发作的抑制作用。拮抗剂APV(d-2-氨基-5-膦-戊酸)、AP-7(d，L-2-氨基-7-膦-庚酸)和CPP(d，l-3-[(±)-2-car☐ypiperazin-4-yl-]-propyl-1-phosphonic酸)可阻断N-甲基-D-天冬氨酸诱发的自发爆发和诱发爆发。CPP，而不是APV或AP-7，可阻止无镁介质诱导的猝发的发生。NMDA拮抗剂不能阻断红藻氨酸、7 mM K+、肥大细胞脱颗粒肽、缺氧或自发爆发引起的爆发。在某些情况下，NMDA拮抗剂诱导自发爆发或增加爆发频率，这是一种前抽搐效应。结论：NMDA受体的激活是CA3区产生猝发的充分条件，但不是必要条件。
Intracellular and extracellular recordings from CA3hippocampal neurons in vitro were used to study the ability of several NMDA (N-methyl-d-aspartate) receptor antagonists to suppress epileptiform bursts induced by NMDA and convulsants not thought to act at NMDA receptors. The antagonists, APV (d-2-amino-5-phosphonovalerate), AP-7 (d,l-2-amino-7-phosphonoheptanoate) and CPP (d,l-3-[(±)-2-car☐ypiperazin-4-yl-]-propyl-1-phosphonic acid), blocked the spontaneous and evoked bursts induced by NMDA. CPP, but not APV or AP-7, prevented the development of bursts induced by Mg-free medium. The NMDA antagonists failed to block bursting induced by kainate, 7 mM K+, mast cell degranulating peptide, anoxia or spontaneous bursting. In some cases the NMDA antagonists induced spontaneous bursts or enhanced burst frequency, a proconvulsant effect. It is concluded that activation of NMDA receptors is sufficient but not necessary for burst generation in the CA3region.
影响因子：
2.5
作者：
KORN, SJ;GIACCHINO, JL;DINGLEDINE, R
通讯作者：
DINGLEDINE, R
影响因子：
2.5
作者：
RUTECKI, PA;LEBEDA, FJ;JOHNSTON, D
通讯作者：
JOHNSTON, D
NMDA 受体拮抗剂 2-氨基-5-磷酸戊酸可阻断刺激序列诱导的癫痫发生，但不会阻断大鼠海马切片中的癫痫样爆发。
影响因子：
2.5
作者：
Anderson,WW;Swartzwelder,HS;Wilson,WA
通讯作者：
Wilson,WA