ACUTE NEUROPATHOLOGICAL CHANGES IN THE CAUDATE-NUCLEUS CAUSED BY MPTP AND METHAMPHETAMINE - IMMUNOHISTOCHEMICAL STUDIES
ACUTE NEUROPATHOLOGICAL CHANGES IN THE CAUDATE-NUCLEUS CAUSED BY MPTP AND METHAMPHETAMINE - IMMUNOHISTOCHEMICAL STUDIES
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DOI：
10.1007/bf01188403
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发表时间：
1990-06-01
期刊：
影响因子：
--
通讯作者：
MCAULIFFE, WG
中科院分区：
文献类型：
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作者：
HESS, A;DESIDERIO, C;MCAULIFFE, WG
给小鼠注射MPTP(1-methyl-4-phenyl-1，2，3，6-tetrahydropyridine)或甲基苯丙胺3天后，尾状核内含酪氨酸羟基酶的点状突触终末变性消失。神经束被较长的静脉曲张的分支纤维占据，这些纤维看起来像是终末前纤维。会发生严重的胶质细胞增多症。稀少出现的胶质细胞，主要位于血管附近，具有丰富的浅染(由胶质纤维酸性蛋白)突起，转化为较深染色的星形细胞，突起较少但较厚。这些细胞分布在整个尾状核中。尽管MPTP甲基苯丙胺导致多巴胺耗竭的机制明显不同，但这些物质引起的尾状核神经病理变化是相同的。
Three days after the administration of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) or methamphetamine to mice, there is degeneration and disappearance of punctate tyrosine hydroxylase-containing synaptic endings in the caudate nucleus. The neuropil is occupied with longer, varicose, branching fibres, which appear to be preterminal fibres. An intense gliosis occurs. The sparsely-occurring glial cells, with profuse lightly-stained (by glial fibrillary acidic protein) processes which are primarily located near blood vessels, become transformed into more heavily-stained star-shaped cells with fewer but thicker processes. These cells are distributed throughout the caudate. Despite apparent differences in the mechanism by which MPTP methamphetamine cause dopamine depletion, the neuropathological changes in the caudate induced by these substances are identical.