HIV Peripheral Neuropathy Pathophysiology and Clinical Implications
HIV Peripheral Neuropathy Pathophysiology and Clinical Implications
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DOI：
10.1097/00044067-200601000-00004
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发表时间：
2006-01-01
影响因子：
2.2
通讯作者：
Morton, Patricia Gonce
中科院分区：
文献类型：
--
作者：
Dorsey, Susan G.;Morton, Patricia Gonce
人类免疫缺陷病毒（HIV）最令人衰弱的神经系统并发症之一是疼痛性周围神经病变，影响近三分之一的患者。虽然HIV感染可引起远端感觉性多发性神经病（DSP），但用于治疗HIV感染的高效抗逆转录病毒疗法（HAART）的出现已导致大量患者发生临床上难以区分的毒性神经病。无论病因如何，主要症状是难以忍受的持续疼痛，对药物治疗有抵抗力，导致进行日常生活活动的能力降低，最终无法行走。由于一般不建议停用核苷类药物，因此通过基础和临床研究努力，对核苷类药物诱导的周围神经病变的病因学和病理生理学有更深入的了解，将有助于开发旨在缓解或改善疼痛的新治疗方法。这篇文章提供了最新的信息有关的病理生理和临床意义的艾滋病毒周围神经病变。
One of the most debilitating neurological complications of human immunodeficiency virus (HIV), affecting nearly one in three patients, is painful peripheral neuropathy. Although HIV infection can cause distal sensory polyneuropathy (DSP), the advent of highly active antiretroviral therapy (HAART) to treat HIV infection has resulted in a significant number of patients developing a clinically indistinguishable form of toxic neuropathy. The predominant symptom, regardless of etiology, is excruciating unremitting pain, resistant to pharmacological treatments, that leads to a reduction in the ability to conduct activities of daily living and, eventually, inability to ambulate. Since withdrawal from nucleoside therapy is not typically recommended, a more thorough understanding of the etiology and pathophysiology underlying nucleoside-induced peripheral neuropathy, through basic and clinical research endeavors, will aid in the development of new therapeutic treatments aimed at alleviating or ameliorating pain. This article provides the latest information regarding the pathophysiology and clinical implications of HIV peripheral neuropathy.