Heterogeneity of pathological prion protein accumulation in the brain of moose (Alces alces) from Norway, Sweden and Finland with chronic wasting disease.
Heterogeneity of pathological prion protein accumulation in the brain of moose (Alces alces) from Norway, Sweden and Finland with chronic wasting disease.
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DOI：
10.1186/s13567-023-01208-3
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发表时间：
2023-09-08
影响因子：
4.4
通讯作者：
中科院分区：
文献类型：
--
作者：
朊病毒疾病是一组影响多种动物的神经退行性、传染性和致命性疾病。它们的特点是细胞朊蛋白（PrPC）的构象转化为病理朊蛋白（PrPSc）。2016年，挪威首次在野生驯鹿（Rangifer tarandus）身上发现了慢性消耗性疾病（CWD），这在欧洲引起了极大的重视。随后在欧洲开展的CWD强化监测导致在驼鹿（Alces Alces）中发现CWD，挪威有11例，芬兰有3例，瑞典有4例。这些驼鹿病例与北美的CWD病例和挪威的驯鹿病例有很大不同，因为PrPSc在大脑中可检测到，但在淋巴组织中未检测到。这些事实表明一种新型CWD的发生。在这里，我们展示了一些免疫组织化学特征，这些特征明显不同于北美和挪威驯鹿的CWD病例。此外，在驼鹿中发现的不同类型的PrPSc沉积物显示了病例之间的强烈差异，支持了这些病例可能携带多种CWD菌株的假设。在线版本包含补充材料，可在10.1186/s13567-023-01208-3获得。
Prion diseases are a group of neurodegenerative, transmissible, and fatal disorders that affect several animal species. They are characterized by the conformational conversion of the cellular prion protein (PrPC) into the pathological prion protein (PrPSc). In 2016, chronic wasting disease (CWD) gained great importance at European level due to the first disease detection in a wild reindeer (Rangifer tarandus) in Norway. The subsequent intensive CWD surveillance launched in cervids resulted in the detection of CWD in moose (Alces alces), with 11 cases in Norway, 3 in Finland and 4 in Sweden. These moose cases differ considerably from CWD cases in North American and reindeer in Norway, as PrPSc was detectable in the brain but not in lymphoid tissues. These facts suggest the occurrence of a new type of CWD. Here, we show some immunohistochemical features that are clearly different from CWD cases in North American and Norwegian reindeer. Further, the different types of PrPSc deposits found among moose demonstrate strong variations between the cases, supporting the postulation that these cases could carry multiple strains of CWD. The online version contains supplementary material available at 10.1186/s13567-023-01208-3.
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影响因子：
4.4
作者：
Benestad SL;Mitchell G;Simmons M;Ytrehus B;Vikøren T
通讯作者：
Vikøren T
影响因子：
6.7
作者：
Bian J;Kim S;Kane SJ;Crowell J;Sun JL;Christiansen J;Saijo E;Moreno JA;DiLisio J;Burnett E;Pritzkow S;Gorski D;Soto C;Kreeger TJ;Balachandran A;Mitchell G;Miller MW;Nonno R;Vikøren T;Våge J;Madslien K;Tran L;Vuong TT;Benestad SL;Telling GC
通讯作者：
Telling GC
影响因子：
11.2
作者：
Dagvadorj, A;Petersen, RB;Goldfarb, LG
通讯作者：
Goldfarb, LG
DOI：
10.1073/pnas.0305777101
发表时间：
2004-03-02
影响因子：
11.1
作者：
Casalone, C;Zanusso, G;Caramelli, M
通讯作者：
Caramelli, M
影响因子：
0.8
作者：
FRASER, H;DICKINSON, AG
通讯作者：
DICKINSON, AG