Peyer's Patches: The Immune Sensors of the Intestine.
Peyer's Patches: The Immune Sensors of the Intestine.
复制标题
DOI：
10.4061/2010/823710
复制
发表时间：
2010-09-19
影响因子：
2
通讯作者：
Barreau F
中科院分区：
文献类型：
--
作者：
Jung C;Hugot JP;Barreau F
肠道相关淋巴组织 (GALT) 由孤立或聚集的淋巴滤泡组成，形成派尔氏淋巴结 (PP)。由于 PP 具有运输腔内抗原和细菌的能力，因此可被视为肠道的免疫传感器。 PP 的功能如诱导免疫耐受或防御病原体，是由位于淋巴滤泡和滤泡相关上皮的免疫细胞之间复杂的相互作用产生的。这种串扰似乎受到病原体识别受体的调节，尤其是 Nod2。尽管 TLR 在 PP 稳态中发挥有限的作用，但 Nod2 可响应肠道菌群调节 PP 的数量、大小和 T 细胞组成。反过来，PP 中存在的 CD4+ T 细胞能够调节细胞旁通透性和跨细胞通透性。克罗恩病和移植物抗宿主病这两种人类疾病被认为是由对共生菌群的异常反应引起的。它们与 NOD2 突变和 PP 功能障碍有关。
The gut-associated lymphoid tissue (GALT) consists of isolated or aggregated lymphoid follicles forming Peyer's patches (PPs). By their ability to transport luminal antigens and bacteria, PPs can be considered as the immune sensors of the intestine. PPs functions like induction of immune tolerance or defense against pathogens result from the complex interplay between immune cells located in the lymphoid follicles and the follicle-associated epithelium. This crosstalk seems to be regulated by pathogen recognition receptors, especially Nod2. Although TLR exerts a limited role in PP homeotasis, Nod2 regulates the number, size, and T-cell composition of PPs, in response to the gut flora. In turn, CD4+ T-cells present in the PP are able to modulate the paracellular and transcellular permeabilities. Two human disorders, Crohn's disease and graft-versus-host disease are thought to be driven by an abnormal response toward the commensal flora. They have been associated with NOD2 mutations and PP dysfunction.