A Change of Osteocalcin (OC) and Tartrate Resistant Acid Phosphatase 5b (TRACP-5b) with the Menstrual Cycle
A Change of Osteocalcin (OC) and Tartrate Resistant Acid Phosphatase 5b (TRACP-5b) with the Menstrual Cycle
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DOI：
10.1055/s-0032-1311606
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发表时间：
2012-09-01
影响因子：
2.2
通讯作者：
Ohta, S.
中科院分区：
文献类型：
--
作者：
Lee, S.;Kumagai, T.;Ohta, S.
对14例无月经紊乱的健康年轻女性进行了4个月经周期相关骨代谢指标的评价。用3个月基础体温、促黄体生成素试剂盒、血清性激素浓度确定月经周期。使用的骨代谢标志物是骨钙素（OC），采用免疫放射测定法（IRMA）测量，以及抗酒石酸酸性磷酸酶5b (TRACP-5b)，采用酶免疫测定法（EIA）测量。OC和TRACP-5b在排卵期最高，且TRACP-5b较月经期显著升高（p < 0.05）。此外，与OC和TRACP-5b相关的性激素分泌变化在月经周期中表现出特定的模式。换句话说，TRACP-5b水平受月经期间产生的性激素的影响，并以骨骼形成状态为基础。因此，推测排卵期间的TRACP-5b水平在骨形成和骨代谢中起核心作用。
Bone metabolism markers associated with 4 menstrual cycle phases were evaluated in 14 healthy young females without menstrual disorder. Menstrual cycle phases were confirmed with basal body temperature for 3 months, luteinizing hormone kits, and sexual hormone concentrations of serum. The bone metabolism markers used were osteocalcin (OC), which was measured by immunoradiometric assay (IRMA), and tartrate resistant acid phosphatase 5b (TRACP-5b), which was measured by enzyme immunometric assay (EIA). The highest values of OC and TRACP-5b were observed in the ovulation phase, and TRACP-5b increased significantly when compared with levels in the menstrual phase (p < 0.05). Furthermore, the changes in sex-hormone secretion involved in OC and TRACP-5b showed specific patterns during the menstrual cycle. In other words, TRACP-5b levels are influenced by sex hormones produced during the menstrual period and are based on the bone-formation status. Therefore, it is presumed that the TRACP-5b levels during ovulation play a central role in bone formation and bone metabolism.