Potential correlation between statins and pulp chamber calcification.
Potential correlation between statins and pulp chamber calcification.
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DOI：
10.1016/j.joen.2013.06.005
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发表时间：
2013-09
影响因子：
4.2
通讯作者：
M. Pettiette;Sheng Zhong;A. Moretti;Asma A. Khan
中科院分区：
文献类型：
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作者：
M. Pettiette;Sheng Zhong;A. Moretti;Asma A. Khan
前言3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂（他汀类）是防治血脂异常的一线药物。最近的研究表明，他汀类药物诱导牙髓干细胞向成牙本质细胞分化。他汀类药物通过上调矿化结节和牙源性标志物促进人牙髓细胞分化。这项研究测试的假设，全身管理他汀类药物的结果增加牙髓calcium.MethodsThis回顾性病例对照研究使用数字咬翼片的下颌磨牙。根据他汀类药物的全身使用情况，将年龄≥60岁的受试者（N= 90）分配至试验组（n = 45）或对照组（n= 45）。使用标准化方法测量髓室的高度和近远中距离。采用卡方检验对数据进行分析。多元线性回归模型分析，探讨他汀类药物摄入量和牙髓calcium.ResultsThree的45个下颌磨牙在测试组表现出几乎完全髓室闭塞之间的关联。与对照组相比，他汀类药物组的髓室高度比显著降低（P<0.0001）。当两组之间的近远中宽度进行比较，没有显着差异（P= .3730）。ConclusionsThe显着增加的钙化和损失的垂直高度的髓室观察到在他汀类药物治疗患者的下颌磨牙表明可能增加成牙本质细胞的活动。因此，全身他汀类药物可能是髓室钙化的一个促成因素。
Introduction3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) are the first-line pharmaceuticals for the prevention and treatment of dyslipidemia. A recent investigation has shown that statins induced odontoblastic differentiation of dental pulp stem cells. Statins enhance the differentiation of human dental pulp cells by up-regulating mineralization nodules and odontogenic markers. This study tested the hypothesis that the systemic administration of statins results in increased dental pulp calcification.MethodsThis retrospective case-control study used digital bitewing radiographs of mandibular molars. Subjects (N= 90) aged ≥60 years were assigned to either test (n = 45) or control (n= 45) groups based on the systemic use of statins. The dimensions of the pulp chambers were measured using a standardized method for height and mesiodistal distances. The chi-square test was used to analyze the data. Multiple linear regression model analysis was performed to explore the association between statin intake and pulp calcification.ResultsThree of the 45 mandibular molars in the test group exhibited almost complete pulp chamber obliteration. There was a significant reduction in pulp chamber height ratio shown in the statin group compared with the control group (P< .0001). When the mesiodistal width was compared between the 2 groups, there was no significant difference (P= .3730).ConclusionsThe significant increase of calcification and loss of vertical height of the pulp chamber observed in mandibular molars in patients on statin medication indicated a possible increased odontoblastic activity. Therefore, systemic statins could be a contributing factor for pulp chamber calcification.