Relationship between physical activity and inflammation among apparently healthy middle-aged and older US adults
Relationship between physical activity and inflammation among apparently healthy middle-aged and older US adults
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DOI：
10.1001/archinte.162.11.1286
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发表时间：
2002-06-10
影响因子：
--
通讯作者：
Vaccarino, V
中科院分区：
文献类型：
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作者：
Abramson, JL;Vaccarino, V
背景资料：体力活动与冠心病风险降低有关，但这种联系的机制尚不清楚。由于冠心病越来越多地被视为一种炎症过程，它可能是合理的假设，体育活动减少或防止inflammation.Methods的冠心病风险降低：该研究探讨了体育活动和炎症升高之间的关系，高C反应蛋白水平，白色血细胞计数，或纤维蛋白原水平。研究对象是3638显然健康的美国男性和女性40岁及以上谁参加了第三次全国健康和营养检查Survey.Results：更频繁的体力活动是独立相关的几率较低，有一个升高的C-反应蛋白水平。与那些每月进行0至3次体育活动的人相比，每月进行4至21次体育活动的人C反应蛋白水平升高的几率降低（比值比，0.77; 95%置信区间，0.58-1.02）和每月22次或以上（比值比，0.63; 95%置信区间，0.43-0.93）（趋势P，0.02）。类似的协会被认为是白色血细胞计数和纤维蛋白原level.Conclusions：更频繁的体力活动是独立相关的明显健康的美国成年人40岁及以上的炎症水平升高的几率较低，独立的几个混杂因素。结果表明，体育活动和降低冠心病风险之间的关联可能是由定期体育活动的抗炎作用介导的。
Background: Physical activity has been associated with a reduced risk of coronary heart disease, but the mechanism underlying this association is unclear. Because coronary heart disease is increasingly seen as an inflammatory process, it might be reasonable to hypothesize that physical activity reduces risk of coronary heart disease by reducing or preventing inflammation.Methods: The study examined the relationship between physical activity and elevated inflammation as indicated by a high C-re-active protein level, white blood cell count, or fibrinogen level. Study subjects were 3638 apparently healthy US men and women 40 years and older who participated in the Third National Health and Nutrition Examination Survey.Results: More frequent physical activity was independently associated with a lower odds of having an elevated C-reactive protein level. Compared with those engaging in physical activity 0 to 3 times per month, the odds of having an elevated C-reactive protein level was reduced among those engaging in physical activity 4 to 21 times per month (odds ratio, 0.77; 95% confidence interval, 0.58-1.02) and 22 or more times per month (odds ratio, 0.63; 95% confidence interval, 0.43-0.93) (P for trend, .02). Similar associations were seen for white blood cell count and fibrinogen levels.Conclusions: More frequent physical activity is independently associated with a lower odds of having elevated inflammation levels among apparently healthy US adults 40 years and older, independent of several confounding factors. The results suggest that the association between physical activity and reduced coronary heart disease risk may be mediated by anti-inflammatory effects of regular physical activity.