Beneficial regulation of matrix metalloproteinases for skin health.
Beneficial regulation of matrix metalloproteinases for skin health.
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DOI：
10.4061/2011/427285
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发表时间：
2011-03-08
期刊：
影响因子：
--
通讯作者：
Gonzalez S
中科院分区：
文献类型：
--
作者：
Philips N;Auler S;Hugo R;Gonzalez S
基质金属蛋白酶（MMP）是细胞外基质重塑所必需的。虽然它们的上调促进衰老和癌症，但它们对表皮分化和预防伤口疤痕至关重要。制药行业在鉴定抑制MMPs以预防或治疗衰老和癌症的产品以及刺激MMPs以预防表皮过度增殖性疾病和伤口疤痕的产品方面很活跃。
Matrix metalloproteinases (MMPs) are essential to the remodeling of the extracellular matrix. While their upregulation facilitates aging and cancer, they are essential to epidermal differentiation and the prevention of wound scars. The pharmaceutical industry is active in identifying products that inhibit MMPs to prevent or treat aging and cancer and products that stimulate MMPs to prevent epidermal hyperproliferative diseases and wound scars.