Cyclooxygenase-1 and -2 isoenzymes
Cyclooxygenase-1 and -2 isoenzymes
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DOI：
10.1016/s1357-2725(98)00152-6
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发表时间：
1999-05-01
影响因子：
4
通讯作者：
Trifan, OC
中科院分区：
文献类型：
--
作者：
Hla, T;Bishop-Bailey, D;Trifan, OC
环氧合酶同工酶（COX-1和cox -2）催化类前列腺素生物合成的限速步骤。COX-1和cox -2基因编码两种同工酶，它们具有重叠但不同的表达模式和功能。生理上，多种细胞外刺激如生长因子、细胞因子和肿瘤启动子在转录和转录后水平上调控COX-1和-2基因的表达。COX-2在类风湿关节炎、结直肠癌和乳腺癌中过度表达。COX途径信号通过质膜定位、g蛋白偶联受体以及核受体产生前列腺素。目前，一些COX-2选择性抑制剂被开发出来，以控制COX-2同工酶的抗炎和抗肿瘤活性。抑制COX同工酶活性和/或表达可能是未来一代抗炎和抗肿瘤药物的基础。(C) 1999 Elsevier Science Ltd.出版版权所有。
The cyclooxygenase isoenzymes (COX-1 and -2) catalyze the rate-limiting steps in prostanoid biosynthesis. COX-1 and -2 genes encode two isoenzymes with overlapping yet distinct expression patterns and functions. Physiologically, various extracellular stimuli such as growth factors, cytokines and tumor promoters regulate the expression of COX-1 and -2 genes at both transcriptional and post-transcriptional levels. COX-2 is overexpressed in rheumatoid arthritis, colorectal and breast cancer. Prostanoids produced by the COX pathway signal via plasma membrane-localized, G-protein-coupled receptors as well as via nuclear receptors, Currently, several COX-2-selective inhibitors are developed to control the anti-inflammatory and anti-neoplastic activities of the COX-2 isoenzyme. Inhibition of the COX isoenzyme activity and/or expression may be the basis of future generation of anti-inflammatory and antineoplastic drugs. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.