VERBAL WORKING-MEMORY DYSFUNCTION IN SCHIZOPHRENIA - USE OF A BROWN-PETERSON PARADIGM
VERBAL WORKING-MEMORY DYSFUNCTION IN SCHIZOPHRENIA - USE OF A BROWN-PETERSON PARADIGM
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DOI：
10.1016/0165-1781(95)02589-3
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发表时间：
1995-03-27
影响因子：
11.3
通讯作者：
WEINBERGER, DR
中科院分区：
文献类型：
--
作者：
FLEMING, K;GOLDBERG, TE;WEINBERGER, DR
精神分裂症的最新研究表明，工作记忆相关过程中存在缺陷，但这些缺陷的认知特征尚未完全确定。我们使用了一种改良的Brown-Peterson范式来比较精神分裂症患者和正常对照组的工作记忆。分心物条件在处理需求上有所不同，从没有分心物到向后计数（连续三）的复杂性增加。我们发现组，干扰条件，和一组x干扰条件的相互作用的显着影响。显着的相互作用是一个更迅速的下降，精神分裂症患者的表现与并发清晰度的结果。此外，精神分裂症患者组也犯了更多的侵入性错误。这项研究表明，精神分裂症患者表现出言语工作记忆系统的功能障碍，由于其整体处理资源的减少。
Recent studies of schizophrenia have implicated deficits in processes related to working memory, but the cognitive features of these deficits have been incompletely characterized. We used a modified Brown-Peterson paradigm to compare working memory in patients with schizophrenia and in normal control subjects. Distracter conditions differed in processing demand, increasing in complexity from no distracter to counting backwards (serial threes). We found significant effects of group, of distracter condition, and of a group x distracter condition interaction. The significant interaction was the result of a more rapid decline in the performance of schizophrenic patients with concurrent articulation. In addition, the schizophrenic group also made significantly more intrusion errors. The study suggests that schizophrenic patients exhibit dysfunction of the verbal working memory system due to a diminution in its overall processing resources.