ESSENTIAL FATTY-ACID STATUS IN NEONATES AFTER FISH-OIL SUPPLEMENTATION DURING LATE PREGNANCY
ESSENTIAL FATTY-ACID STATUS IN NEONATES AFTER FISH-OIL SUPPLEMENTATION DURING LATE PREGNANCY
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DOI：
10.1079/bjn19950175
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发表时间：
1995-11-01
影响因子：
3.6
通讯作者：
SECHER, NJ
中科院分区：
文献类型：
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作者：
VANHOUWELINGEN, AC;SORENSEN, JD;SECHER, NJ
从妊娠第30周至分娩，健康孕妇（n 23）补充鱼油胶囊（2.7 gn -3多不饱和脂肪酸/d），对照组（n 6）补充橄榄油胶囊（4 g/d, n 10）或不补充（n 10），测定从脐带血浆和脐带动脉和静脉血管壁分离的磷脂的脂肪酸组成。同时测定了母体静脉血浆磷脂的脂肪酸组成，鱼油补充组的母体血浆磷脂含有更多的n-3脂肪酸，较少的n-6脂肪酸，必需脂肪酸缺乏标志物Mead酸（20:3n-9）和Osbond酸（22:5n-6）的含量显著降低，母体额外摄入的n-3脂肪酸导致母体n-3脂肪酸含量升高。特别是在脐带血浆和血管壁的磷脂中，确实有可能干扰出生时的二十二碳六烯酸状态：在怀孕最后三个月补充鱼油的母亲所生的孩子在出生时具有较好的二十二碳六烯酸状态，这可能有利于新生儿的神经发育。
Healthy pregnant women (n 23) were supplemented with fish-oil capsules (2.7 g n-3 polyunsaturated fatty acids/d) from the 30th week of gestation until delivery, Subjects in a control group were either supplemented with olive-oil capsules (4 g/d, n 6) or received no supplementation (n 10), Fatty acid compositions of the phospholipids isolated from umbilical plasma and umbilical arterial and venous vessel walls were determined, Fatty acid compositions of maternal venous plasma phospholipids were determined as well, Maternal plasma phospholipids of the fish-oil-supplemented group contained more n-3 fatty acids and less n-6 fatty acids, Moreover, the amounts of the essential fatty acid deficiency markers Mead acid (20:3n-9) and Osbond acid (22:5n-6) were significantly lower, The extra amount of n-3 fatty acids consumed by the mothers resulted in higher contents of n-3 fatty acids, and of docosahexaenoic acid (22:6n-3) in particular, in the phospholipids of umbilical plasma and vessel walls, It is, indeed, possible to interfere with the docosahexaenoic acid status at birth: children born to mothers supplemented with fish oil in the last trimester of pregnancy start with a better docosahexaenoic acid status at birth, which may be beneficial to neonatal neurodevelopment.