Transcription factor, SP1, in epiretinal membranes of patients with proliferative diabetic retinopathy.
Transcription factor, SP1, in epiretinal membranes of patients with proliferative diabetic retinopathy.
复制标题
DOI：
10.1016/j.diabres.2009.12.008
复制
发表时间：
2010-03
影响因子：
5.1
通讯作者：
Natsuyo Yoshida-Hata;Y. Mitamura;T. Oshitari;K. Namekata;C. Harada;T. Harada;S. Yamamoto
中科院分区：
文献类型：
--
作者：
Natsuyo Yoshida-Hata;Y. Mitamura;T. Oshitari;K. Namekata;C. Harada;T. Harada;S. Yamamoto
增殖型糖尿病视网膜病变（proliferative diabetic retinopathy，PDR）视网膜前膜中SP1 mRNA高表达，SP1蛋白主要与血管内皮生长因子（vascular endothelial growth factor，VEGF）共定位。SP1可能通过调节血管生成相关因子基因的表达和启动子活性，在PDR血管生成中发挥重要作用。
SP1 mRNA was highly expressed in the epiretinal membranes of proliferative diabetic retinopathy (PDR), and the SP1 protein was mainly co-localized with vascular endothelial growth factor. SP1 might play an important role in the angiogenesis of PDR by regulating the promoter activity and expression of genes encoding angiogenesis-related factors.