The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation
The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation
复制标题
DOI：
10.1002/oby.21199
复制
发表时间：
2015-01-01
期刊：
影响因子：
6.9
通讯作者：
Poulain-Godefroy, Odile
中科院分区：
文献类型：
--
作者：
Favennec, Marie;Hennart, Benjamin;Poulain-Godefroy, Odile
本研究通过评估犬尿氨酸的循环水平和脂肪组织中KP酶的表达来表征人类肥胖中的犬尿氨酸途径（KP）。队列（病例队列研究：212例糖尿病患者，836例随机抽样）和ABOS队列中的肥胖、糖尿病或血糖正常的女性（n=100）。KP酶的基因表达进行了分析，在网膜和皮下脂肪组织的妇女从ABOS队列，在人类原代脂肪细胞和单核细胞衍生的巨噬细胞。队列中，犬尿氨酸水平与体重指数（BMI）（P=4.68 x 10（-19））和较高的HOMA 2-IR胰岛素抵抗指数（P=6.23 x 10（-4））呈正相关。犬尿氨酸、犬尿烯酸和喹啉酸水平与较高的BMI相关（P
ObjectiveThis study characterized the kynurenine pathway (KP) in human obesity by evaluating circulating levels of kynurenines and the expression of KP enzymes in adipose tissue.MethodsTryptophan and KP metabolite levels were measured in serum of individuals from the D.E.S.I.R. cohort (case-cohort study: 212 diabetic, 836 randomly sampled) and in women with obesity, diabetic or normoglycemic, from the ABOS cohort (n=100). KP enzyme gene expressions were analyzed in omental and subcutaneous adipose tissue of women from the ABOS cohort, in human primary adipocytes and in monocyte-derived macrophages.ResultsIn the D.E.S.I.R. cohort, kynurenine levels were positively associated with body mass index (BMI) (P=4.68 x 10(-19)) and with a higher HOMA2-IR insulin resistance index (P=6.23 x 10(-4)). The levels of kynurenine, kynurenic acid, and quinolinic acid were associated with higher BMI (P