High dose versus standard dose epinephrine in cardiac arrest - a meta-analysis
High dose versus standard dose epinephrine in cardiac arrest - a meta-analysis
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DOI：
10.1016/s0300-9572(00)00188-x
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发表时间：
2000-08-01
期刊：
影响因子：
6.5
通讯作者：
Martens, P
中科院分区：
文献类型：
--
作者：
Vandycke, C;Martens, P
在心脏骤停的管理中，关于肾上腺素的最佳剂量一直存在争议。为了获得关于当前最佳剂量的最佳可用证据，我们进行了荟萃分析。我们在线检索了Medline数据库，并回顾了相关文章的引文，以确定符合预设纳入标准（前瞻性、随机、双盲）的研究。确定了五项审判。自发循环恢复的合并比值比有利于实验剂量。出院的合并比值比未能证明高剂量和/或递增剂量肾上腺素与标准剂量肾上腺素相比具有统计学显著性有益作用。已经遭受不可逆神经损伤的患者将被复苏的可能性具有潜在的不良社会和经济影响。(C)2000爱思唯尔科学爱尔兰有限公司保留所有权利。
In the management of cardiac arrest there is ongoing controversy concerning the optimal dose of epinephrine. To obtain the best available evidence regarding the current optimal dose, we performed a meta-analysis. We searched the Medline database online and reviewed citations in relevant articles to identify studies that met preset inclusion criteria (prospective, randomized, double-blind). Five trials were identified. The pooled odds ratio for return of spontaneous circulation favours the experimental dose. The pooled odds ratio for hospital discharge failed to demonstrate a statistically significant beneficial effect of high and/or escalating doses of epinephrine in comparison with standard dose of epinephrine. The possibility that patients who have already sustained irreversible neurologic injury will be resuscitated carries potential adverse social and economic implications. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.