Unusual Novel SnoRNA-Like RNAs in Drosophila melanogaster.
Unusual Novel SnoRNA-Like RNAs in Drosophila melanogaster.
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DOI：
10.3390/ncrna1020139
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发表时间：
2015-07-13
期刊：
影响因子：
4.3
通讯作者：
Furia M
中科院分区：
文献类型：
--
作者：
Agrisani A;Tafer H;Stadler PF;Furia M
果蝇中新型小核RNA的计算屏幕发现了15个新型SNORNA和类似SNORNA的长期非编码RNA。与较早的勘测相反，新型序列大多是保守的，并且源自不同寻常的基因组位置。多数属于原始反义对众所周知的蛋白质编码基因，其中四个是由外显子编码区域产生的。只有少数新序列似乎具有核糖体或小核RNA中的规范目标位点。综上所述，这些进化的年轻，保守的且基因组非典型序列指向一类类似SNORNA的转录本，在果蝇基因组中主要具有调节功能。
A computational screen for novel small nucleolar RNAs in Drosophila melanogaster uncovered 15 novel snoRNAs and snoRNA-like long non-coding RNAs. In contrast to earlier surverys, the novel sequences are mostly poorly conserved and originate from unusual genomic locations. The majority derive from precurors antisense to well-known protein-coding genes, and four of the candidates are produced from exon-coding regions. Only a minority of the new sequences appears to have canonical target sites in ribosomal or small nuclear RNAs. Taken together, these evolutionary young, poorly conserved, and genomically atypical sequences point at a class of snoRNA-like transcripts with predominantly regulatory functions in the fruit fly genome.