ACETYLCHOLINE LIBERATION FROM CEREBRAL CORTEX DURING PARADOXICAL (REM) SLEEP
ACETYLCHOLINE LIBERATION FROM CEREBRAL CORTEX DURING PARADOXICAL (REM) SLEEP
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DOI：
10.1126/science.172.3983.601
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发表时间：
1971-01-01
期刊：
影响因子：
56.9
通讯作者：
TESSIER, J
中科院分区：
文献类型：
--
作者：
JASPER, HH;TESSIER, J
本文测定了猫在慢波睡眠、异相睡眠或激活睡眠和清醒状态下，经前列腺素处理的猫大脑皮质表面游离乙酰胆碱的释放率。慢波睡眠期间的平均速率(每平方厘米皮质表面1.2毫微克)在反常睡眠(每分钟2.2毫微克)和清醒时(每分钟2.1毫微克)增加。因此，乙酰胆碱的释放速率与大脑皮质去同步激活的脑电模式有关，而不是与动物的行为反应有关。
The rate of liberation of free acetylcholine from the surface of prostigmin-treated cerebral cortex in the freely moving cat has been determined in states of slow wave sleep, paradoxical or activated sleep, and waking. The average rate during slow wave sleep (1.2 nanograms per minute per square centimeter of cortical surface) increased during paradoxical sleep (2.2 nanograms per minute) and during waking (2.1 nanograms per minute). The rate of acetylcholine release is thus related to the electroencephalogram pattern of desynchronized activation of the cortex rather than to the behavioral responsiveness of the animals.