Human Mesenchymal Stromal Cells from Different Sources Diverge in Their Expression of Cell Surface Proteins and Display Distinct Differentiation Patterns.
Human Mesenchymal Stromal Cells from Different Sources Diverge in Their Expression of Cell Surface Proteins and Display Distinct Differentiation Patterns.
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DOI：
10.1155/2016/5646384
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发表时间：
2016
影响因子：
4.3
通讯作者：
Aicher WK
中科院分区：
文献类型：
--
作者：
Elahi KC;Klein G;Avci-Adali M;Sievert KD;MacNeil S;Aicher WK
当无菌细胞培养成为实验室常规时，人们对使用这种新技术治疗疾病或替换受伤、炎症或癌症患者的细胞，甚至更新老年人的细胞寄予厚望。今天，在第一次成功的骨髓移植50多年后，造血干细胞的临床应用是一个常规程序，每天挽救许多人的生命。然而，造血干细胞和祖细胞以外的移植仍仅限于少数应用，主要适用于从骨髓中分离的间充质基质细胞（MSC）。但是研究进展和不同的试验探索了从骨髓分离的人MSC的临床潜力，但也从其他组织包括脂肪组织分离。最近，从骨髓中分离的MSC（bmMSC）被证明是不同细胞的混合物，并且从不同组织中分离的MSC除了一些共同的特征之外还显示出一些显著的差异。这包括在MSC的子集上表达不同的抗原，其最近被用于从大量MSC中定义和分离功能上不同的子集。因此，我们简要讨论了人类骨髓间充质干细胞亚群和从其他来源分离的骨髓间充质干细胞中发现的差异，并探讨了如何将其用于基于细胞的治疗。
When germ-free cell cultures became a laboratory routine, hopes were high for using this novel technology for treatment of diseases or replacement of cells in patients suffering from injury, inflammation, or cancer or even refreshing cells in the elderly. Today, more than 50 years after the first successful bone marrow transplantation, clinical application of hematopoietic stem cells is a routine procedure, saving the lives of many every day. However, transplanting other than hematopoietic stem and progenitor cells is still limited to a few applications, and it mainly applies to mesenchymal stromal cells (MSCs) isolated from bone marrow. But research progressed and different trials explore the clinical potential of human MSCs isolated from bone marrow but also from other tissues including adipose tissue. Recently, MSCs isolated from bone marrow (bmMSCs) were shown to be a blend of distinct cells and MSCs isolated from different tissues show besides some common features also some significant differences. This includes the expression of distinct antigens on subsets of MSCs, which was utilized recently to define and separate functionally different subsets from bulk MSCs. We therefore briefly discuss differences found in subsets of human bmMSCs and in MSCs isolated from some other sources and touch upon how this could be utilized for cell-based therapies.