Temperature dependence of DNA condensation at high ionic concentration
Temperature dependence of DNA condensation at high ionic concentration
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DOI：
10.1142/s0217984916502985
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发表时间：
2016-08
影响因子：
1.9
通讯作者：
W. Mao;Qingqing Gao;Yanhui Liu;Yangtao Fan;Lin Hu;Hou-Qiang Xu
中科院分区：
文献类型：
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作者：
W. Mao;Qingqing Gao;Yanhui Liu;Yangtao Fan;Lin Hu;Hou-Qiang Xu
一系列的实验表明，多价阳离子凝聚的DNA的致密态更倾向于高温。凝聚的DNA采取伸长的卷曲或紧凑的小球状态，并且紧凑的小球状态的群体随着温度的升高而增加。同时，最近在不含多价阳离子的缓冲溶液中进行的实验工作指出，DNA的持久长度强烈地依赖于温度。DNA持久长度是定量解释DNA构象性质的关键参数，与DNA的弯曲刚度有关。考虑到存留长度的温度依赖性对DNA凝聚的影响，提出了一个包含存留长度的温度依赖性和多价阳离子与DNA的强相关性的模型。切向量的自相关函数被发现作为一种有效的方法来检测环构象的温度依赖性。随着增长…
A series of experiments pointed out that compact states of DNA condensed by multivalent cation prefer higher temperature. The condensed DNA takes elongated coil or compact globule states and the population of the compact globule states increases with an increase in temperature. At the same time, a recent experimental work carried out in buffer solution without multivalent cation points out that DNA persistence length strongly depends on the temperature. DNA persistence length is a key parameter for quantitative interpretation of the conformational properties of DNA and related to the bending rigidity of DNA. It is necessary to revolve the effects of temperature dependence of persistence length on DNA condensation, and a model including the temperature dependence of persistence length and strong correlation of multivalent cation on DNA is provided. The autocorrelation function of the tangent vectors is found as an effective way to detect the temperature dependence of toroid conformations. With an increase ...