ROLE OF FLAVONOIDS IN SUPPRESSING THE ENHANCEMENT OF PHOSPHOLIPID-METABOLISM BY TUMOR PROMOTERS
ROLE OF FLAVONOIDS IN SUPPRESSING THE ENHANCEMENT OF PHOSPHOLIPID-METABOLISM BY TUMOR PROMOTERS
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DOI：
10.1016/0304-3835(83)90075-7
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发表时间：
1983-01-01
期刊：
影响因子：
9.7
通讯作者：
SUGIMURA, T
中科院分区：
文献类型：
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作者：
NISHINO, H;NAGAO, M;SUGIMURA, T
槲皮素是一种普遍存在于植物中的类黄酮，可抑制[32P]无机磷酸盐（32Pi）进入HeLa[人宫颈癌]细胞的磷脂，而12- o - tetradecanoylphorbol13 -acetate （TPA）是一种有效的肿瘤启动子。在所测试的黄酮类化合物中，木犀草素对TPA的抑制作用最有效。构效关系研究表明，羟化黄酮和黄酮醇含量越高，抑制作用越强。槲皮素和木犀草素还抑制了另一种有效的肿瘤启动子——二氢远杀素B对32pi与磷脂结合的增强作用。槲皮素对肿瘤启动子的生物作用的抑制作用是有趣的，这与这种类黄酮在动物身上的非致癌性有关，尽管它具有致突变性。
Quercetin, a ubiquitous flavonoid in plants, inhibited the incorporation of [32P]inorganic phosphate (32Pi) into phospholipid of HeLa [human cervical carcinoma] cells enhanced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter. Among the flavonoids tested, luteolin was the most effective in inhibiting the action of TPA. Studies on structure-activity relationships demonstrated that more hydroxylated flavones and flavonols had stronger inhibitory effects. Quercetin and luteolin also inhibited enhancement of 32Pi-incorporation into phospholipid by dihydroteleocidin B, another potent tumor promoter. The inhibitory effect of quercetin on the biological action of tumor promoters is interesting in relation to the non-carcinogenicity of this flavonoid in animals, in spite of its mutagenicity.