Hierarchical organization of modularity in metabolic networks
Hierarchical organization of modularity in metabolic networks
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DOI：
10.1126/science.1073374
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发表时间：
2002-08-30
期刊：
影响因子：
56.9
通讯作者：
Barabási, AL
中科院分区：
文献类型：
--
作者：
Ravasz, E;Somera, AL;Barabási, AL
空间或化学隔离的功能模块组成的几个细胞成分和携带离散的功能被认为是细胞组织的基本构件，但它们的存在，在高度集成的生化网络缺乏定量支持。在这里，我们发现，43个不同的生物体的代谢网络被组织成许多小的，高度连接的拓扑模块，联合收割机以分层的方式组合成更大的，凝聚力较低的单位，其数量和聚类程度遵循幂律。在大肠杆菌中，未发现的层次模块性与已知的代谢功能密切重叠。所识别的网络架构对于系统级蜂窝组织可以是通用的。
Spatially or chemically isolated functional modules composed of several cellular components and carrying discrete functions are considered fundamental building blocks of cellular organization, but their presence in highly integrated biochemical networks lacks quantitative support. Here, we show that the metabolic networks of 43 distinct organisms are organized into many small, highly connected topologic modules that combine in a hierarchical manner into larger, less cohesive units, with their number and degree of clustering following a power law. Within Escherichia coli, the uncovered hierarchical modularity closely overlaps with known metabolic functions. The identified network architecture may be generic to system-level cellular organization.