PREDICTING THE OUTCOME OF ENDOMETRIAL HYPERPLASIA BY QUANTITATIVE-ANALYSIS OF NUCLEAR FEATURES USING A LINEAR DISCRIMINANT FUNCTION
PREDICTING THE OUTCOME OF ENDOMETRIAL HYPERPLASIA BY QUANTITATIVE-ANALYSIS OF NUCLEAR FEATURES USING A LINEAR DISCRIMINANT FUNCTION
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DOI：
10.1097/00004347-198301040-00004
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发表时间：
1983-01-01
影响因子：
2.4
通讯作者：
FOX, CH
中科院分区：
文献类型：
--
作者：
COLGAN, TJ;NORRIS, HJ;FOX, CH
本文应用图形板和微机测定了24例子宫内膜不典型增生的细胞核参数。24例增生中有8例进展为癌，但其余16例在平均11.8年的随访期内没有进展。线性判别函数选择最大核直径的平均值和标准差作为临床结果的有用预测因子。线性判别函数在83%的病例中预测了正确的结果。这项研究表明，核参数的测量在子宫内膜不典型增生可能提供一个更客观的手段预测的各种形式的增生的行为。
Nuclear parameters from 24 cases of atypical endometrial hyperplasia were determined by means of graphic tablet and microcomputer. Eight of the 24 hyperplasias progressed to carcinoma, but the remaining 16 did not progress during a mean follow-up period of 11.8 years. A linear discriminant function selected the mean and standard deviation of maximal nuclear diameter as useful predictors of clinical outcome. The linear discriminant function predicted the correct outcome in 83% of the cases. This study suggests that measurement of nuclear parameters in atypical endometrial hyperplasia may provide a more objective means of predicting the behavior of the various forms of hyperplasia.