Reduced hippocampal N-acetylaspartate without volume loss in schizophrenia
Reduced hippocampal N-acetylaspartate without volume loss in schizophrenia
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DOI：
10.1016/s0920-9964(98)00173-x
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发表时间：
1999-06-22
影响因子：
4.5
通讯作者：
Amend, D
中科院分区：
文献类型：
--
作者：
Deicken, RF;Pegues, M;Amend, D
定量磁共振成像（MRI）可以测量总的灰质体积，但不能区分神经元和神经胶质。质子磁共振波谱成像（H-1 MRSI）测量n -乙酰天冬氨酸（NAA），它是神经元丢失或神经元功能障碍的选择性标志物。本研究的目的是获得海马体积和海马NAA的定量测量，以确定是否存在精神分裂症海马神经元功能障碍或神经元丢失的证据。对23例慢性精神分裂症患者和18例对照者的左右海马区进行定量MRI和H-1 MRI检查。与对照组相比，精神分裂症患者双侧海马体积没有变化，但双侧海马区NAA明显降低。在精神分裂症患者和对照组中，海马体体积和NAA之间也没有相关性。这些发现表明：(1)海马NAA可能是比体积测量更敏感的神经元损失测量方法；(2)海马体NAA的减少可能是衡量精神分裂症患者神经元功能障碍或损伤，而不是神经元损失。(C) 1999 Elsevier Science B.V.版权所有
Quantitative magnetic resonance imaging (MRI) can measure total gray matter volume but cannot discriminate between neurons and glia. Proton magnetic resonance spectroscopic imaging (H-1 MRSI) measures N-acetylaspartate (NAA) which is a selective marker of neuronal loss or neuronal dysfunction. The objective of this study was to obtain quantitative measures of hippocampal volume and hippocampal NAA to determine if there was evidence for hippocampal neuronal dysfunction or neuronal loss in schizophrenia. Quantitative MRI and H-1 MRSI was performed on the right and left hippocampal regions in 23 chronic schizophrenic patients and 18 control subjects. Relative to the control group, the patients with schizophrenia demonstrated no change in hippocampal volumes bilaterally, but significantly decreased NAA in the hippocampal regions bilaterally. There was also no correlation between hippocampal volumes and NAA in either the schizophrenics or controls. These findings suggest that: (I) hippocampal NAA may be a more sensitive measure of neuronal loss than Volumetric measurements; and (2) reduced hippocampal NAA may be measuring neuronal dysfunction or damage rather than neuronal loss in this sample of schizophrenics. (C) 1999 Elsevier Science B.V. All rights reserved.