Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses
Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses
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DOI：
10.1038/s41598-020-67211-2
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发表时间：
2020-06-24
影响因子：
4.6
通讯作者：
Brenner, David J.
中科院分区：
文献类型：
--
作者：
Buonanno, Manuela;Welch, David;Brenner, David J.
限制空气传播病毒的直接方法是在病毒产生后的短时间内使其失活。通常波长为254纳米的杀菌紫外线在这种情况下是有效的，但直接使用可能会对皮肤和眼睛造成健康危害。相比之下，远紫外线（207-222纳米）可以有效地杀死病原体，而不会对暴露的人体组织造成伤害。我们之前证明了222 nm远紫外线光能有效杀死空气传播的流感病毒，我们将这些研究扩展到探索远紫外线光对空气传播的人类冠状病毒α HCoV-229E和β HCoV-OC43的功效。低剂量1.7和1.2 mJ/cm(2)分别灭活了99.9%的雾化冠状病毒229E和OC43。由于所有人类冠状病毒都具有相似的基因组大小，因此远紫外线光对包括SARS-CoV-2在内的其他人类冠状病毒的灭活效率预计相似。根据β - hcov - oc43的结果，在目前的监管暴露限值（类似于3 mJ/cm(2)/小时）下，在有人居住的公共场所持续暴露远紫外线将导致病毒在大约8分钟内灭活90%，在大约11分钟内灭活95%，在大约16分钟内灭活99%，在大约25分钟内灭活99.9%。因此，在保持在目前的监管剂量限制范围内的情况下，低剂量率的远紫外线暴露可能安全地大大降低被占领的公共场所空气传播的冠状病毒的环境水平。
A direct approach to limit airborne viral transmissions is to inactivate them within a short time of their production. Germicidal ultraviolet light, typically at 254 nm, is effective in this context but, used directly, can be a health hazard to skin and eyes. By contrast, far-UVC light (207-222 nm) efficiently kills pathogens potentially without harm to exposed human tissues. We previously demonstrated that 222-nm far-UVC light efficiently kills airborne influenza virus and we extend those studies to explore far-UVC efficacy against airborne human coronaviruses alpha HCoV-229E and beta HCoV-OC43. Low doses of 1.7 and 1.2 mJ/cm(2) inactivated 99.9% of aerosolized coronavirus 229E and OC43, respectively. As all human coronaviruses have similar genomic sizes, far-UVC light would be expected to show similar inactivation efficiency against other human coronaviruses including SARS-CoV-2. Based on the beta-HCoV-OC43 results, continuous far-UVC exposure in occupied public locations at the current regulatory exposure limit (similar to 3 mJ/cm(2)/hour) would result in similar to 90% viral inactivation in similar to 8 minutes, 95% in similar to 11 minutes, 99% in similar to 16 minutes and 99.9% inactivation in similar to 25 minutes. Thus while staying within current regulatory dose limits, low-dose-rate far-UVC exposure can potentially safely provide a major reduction in the ambient level of airborne coronaviruses in occupied public locations.