Serum polychlorinated biphenyl (PCB) levels and risk of testicular germ cell tumors: A population-based case-control study in Connecticut and Massachusetts
Serum polychlorinated biphenyl (PCB) levels and risk of testicular germ cell tumors: A population-based case-control study in Connecticut and Massachusetts
复制标题
DOI：
10.1016/j.envpol.2021.116458
复制
发表时间：
2021-01-19
影响因子：
8.9
通讯作者：
Zheng, Tongzhang
中科院分区：
文献类型：
--
作者：
Cheng, Zhiyuan;Zhang, Xichi;Zheng, Tongzhang
睾丸生殖细胞肿瘤（TGCT）的发病率在过去几十年中在西方国家不断增加。一些流行病学研究报道，血清中的内分泌干扰物多氯联苯（PCBs）可能与TGCT风险有关，但证据不一致。我们的目标是调查是否与TGCT风险增加的多氯联苯血清水平。我们对308例TGCT病例和323例对照进行了基于人群的病例对照研究，所有患者均来自康涅狄格州和马萨诸塞州。采用气相色谱法测定了56种PCB同系物的血清水平，并采用非条件Logistic回归模型评估了与总PCB暴露、按Wolff功能组分类的PCB组和单个PCB同系物相关的TGCT风险。结果显示，血清中多氯联苯总水平与总体TGCT风险之间没有相关性（四分位数4（Q4）与四分位数1（Q1）比值比（OR）和95%置信区间（C.I.）= 1.0（0.6-1.9），rho趋势= 0.9）。然而，观察到Wolff第1组（潜在雌激素）PCB的总血清水平与总体TGCT风险之间存在强正相关（Q4与Q1 OR = 2.5，95%CI = 1.3-4.7，rho趋势
The incidence rate of testicular germ cell tumors (TGCT) has continuously increased in Western countries over the last several decades. Some epidemiologic studies have reported that the endocrine disrupting polychlorinated biphenyls (PCBs) in serum may be associated with TGCT risk, but the evidence is inconsistent. Our goal was to investigate whether serum levels of PCBs are associated with the increase of TGCT risk. We conducted a population-based case-control study of 308 TGCT cases and 323 controls, all residents of Connecticut and Massachusetts. Serum levels of 56 PCBs congeners were measured using gas chromatography and unconditional logistic regression model was used to evaluate the risk of TGCT associated with total PCBs exposure, groups of PCBs categorized by Wolff's functional groups, and individual PCB congeners. The results showed that there was no association between total serum levels of PCBs and risk of TGCT overall (quartile 4 (Q4) vs. quartile 1 (Q1) odds ratio (OR) and 95% confidence interval (C.I.) = 1.0 (0.6-1.9), rho trend = 0.9). However, strong positive association was observed between total serum levels of Wolff's Group 1 (potentially estrogenic) PCBs and risk of overall TGCT (Q4 vs. Q1 OR = 2.5, 95% CI = 1.3-4.7, rho trend