Regulation of Ras signaling by the cell cycle.
Regulation of Ras signaling by the cell cycle.
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DOI：
10.1016/s0959-437x(01)00262-3
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发表时间：
2002-02
影响因子：
4
通讯作者：
D. Stacey;A. Kazlauskas
中科院分区：
文献类型：
--
作者：
D. Stacey;A. Kazlauskas
众所周知，Ras 活性的上调可以促进细胞周期的进展。现在最近的研究表明，也存在着一种相互关系。也就是说，Ras 信号传导的结果取决于细胞周期位置。在用生长因子刺激的静止细胞中，当细胞从 G0 期转变为 G1 期，然后进入 G1 期时，一种 Ras 效应子（磷脂酰肌醇 3-激酶）被激活两次。只有在 G1 期后期，PI3K 活性才会促进进入 S 期。在循环细胞中，Ras 活性在整个细胞周期中增强，但仅在 G2 期才能刺激细胞周期蛋白 D1 升高。
It is well known that upregulation of Ras activity can promote cell-cycle progression. Now recent studies indicate that a reciprocal relationship also exists; that is, the consequences of Ras signaling are dependent upon cell-cycle position. In quiescent cells stimulated with growth factors, one Ras effector, phosphatidylinositol-3-kinase, is activated twiceas cells transition from G0into G1phase, and then later in G1phase. It is only during the later stages of G1phase that PI3K activity promotes entry into S-phase. In cycling cells, Ras activity is enhanced throughout the cell cycle, but is able to stimulate cyclin D1 elevation only during G2phase.