Patient-Reported Outcomes in Adults With Congenital Heart Disease Following Hospitalization (from APPROACH-IS)
Patient-Reported Outcomes in Adults With Congenital Heart Disease Following Hospitalization (from APPROACH-IS)
复制标题
成人先天性心脏病住院后患者报告的结果（来自 APPROACH-IS）
DOI：
10.1016/j.amjcard.2020.12.088
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
et al.
中科院分区：
文献类型：
--
作者：
Moons;P.;Luyckx;K.;Thomet;C.,Budts;W.;Enomoto;J.;et al.
在这项国际研究中，我们（1）比较了在过去12个月内住院与未住院的先天性心脏病（CHD）成人患者的患者报告结局（PRO），（2）对比了因心脏手术与非手术原因住院的患者的PRO，（3）评估了两组之间差异的大小（即，效应量），和（4）探索了国家之间的差异效应量。APPROACH-IS是一项横断面观察性研究，入组了来自15个国家的4，028例患者（中位年龄32岁; 53%为女性）。采用自我报告问卷来测量PRO：健康状况;焦虑和抑郁;生活质量。总体而言，668名患者（17%）在过去12个月内住院。这些患者报告所有PRO的结果较差，但焦虑除外。与那些因非手术原因住院的患者相比，接受心脏手术的患者表现出更好的生活质量。对于显著性差异，效应量很小，而在非显著性比较中可以忽略不计。观察到国家间的巨大差异。对于各种PRO，比较不同国家发现了中等至大的效应量。总之，在前一年住院治疗的CHD成人患者的PRO比那些病情稳定的患者差。研究人员在进行PRO研究时应该考虑招募的时间，因为住院会影响结果。
In this international study, we (1) compared patient-reported outcomes (PROs) in adults with congenital heart disease (CHD) who had versus had not been hospitalized during the previous 12 month, (2) contrasted PROs in patients who had been hospitalized for cardiac surgery versus nonsurgical reasons, (3) assessed the magnitude of differences between the groups (i.e., effect sizes), and (4) explored differential effect sizes between countries. APPROACH-IS was a cross-sectional, observational study that enrolled 4,028 patients from 15 countries (median age 32 years; 53% females). Self-report questionnaires were administered to measure PROs: health status; anxiety and depression; and quality of life. Overall, 668 patients (17%) had been hospitalized in the previous 12 months. These patients reported poorer outcomes on all PROs, with the exception of anxiety. Patients who underwent cardiac surgery demonstrated a better quality of life compared with those who were hospitalized for nonsurgical reasons. For significant differences, the effect sizes were small, whereas they were negligible in nonsignificant comparisons. Substantial intercountry differences were observed. For various PROs, moderate to large effect sizes were found comparing different countries. In conclusion, adults with CHD who had undergone hospitalization in the previous year had poorer PROs than those who were medically stable. Researchers ought to account for the timing of recruitment when conducting PRO research as hospitalization can impact results.