Neighborhood disadvantage reduces cognitive reserve independent of neuropathologic change.
Neighborhood disadvantage reduces cognitive reserve independent of neuropathologic change.
复制标题
邻里劣势会降低认知储备，而与神经病理学变化无关。
DOI：
10.1002/alz.13736
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Lee,EdwardB
中科院分区：
文献类型：
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作者：
Kim,Boram;Yannatos,Isabel;Blam,Kaitlin;Wiebe,Douglas;Xie,SharonX;McMillan,CoreyT;Mechanic-Hamilton,Dawn;Wolk,DavidA;Lee,EdwardB
简介 社会经济弱势社区的个人认知功能受损的风险增加。这种关联是否与主要的痴呆相关神经病理学相关尚不清楚。 方法这项横断面研究包括 2011 年至 2023 年的 469 例尸检病例。通过划分为三分位的面积剥夺指数 (ADI) 百分位数测量的邻里劣势、通过死亡前最后一次简易精神状态检查 (MMSE) 评分评估的认知、以及 10 种痴呆相关蛋白病和脑血管疾病之间的关系使用回归分析进行评估。结果较高的 ADI 与较低的 MMSE 评分显着相关。随着教育年限的增加，这种情况得到了缓解。 ADI 与痴呆相关神经病理变化的增加无关。此外，即使在控制了主要痴呆相关蛋白病或脑血管疾病的变化后，ADI 与认知之间的显着关联仍然存在。讨论邻里劣势似乎与认知储备下降有关。这种关联会因教育而改变，但独立于与痴呆相关的主要神经病理学。
INTRODUCTIONIndividuals in socioeconomically disadvantaged neighborhoods exhibit increased risk for impaired cognitive function. Whether this association relates to the major dementia‐related neuropathologies is unknown.METHODSThis cross‐sectional study included 469 autopsy cases from 2011 to 2023. The relationships between neighborhood disadvantage measured by Area Deprivation Index (ADI) percentiles categorized into tertiles, cognition evaluated by the last Mini‐Mental State Examination (MMSE) scores before death, and 10 dementia‐associated proteinopathies and cerebrovascular disease were assessed using regression analyses.RESULTSHigher ADI was significantly associated with lower MMSE score. This was mitigated by increasing years of education. ADI was not associated with an increase in dementia‐associated neuropathologic change. Moreover, the significant association between ADI and cognition remained even after controlling for changes in major dementia‐associated proteinopathies or cerebrovascular disease.DISCUSSIONNeighborhood disadvantage appears to be associated with decreased cognitive reserve. This association is modified by education but is independent of the major dementia‐associated neuropathologies.