Modulation by leptin of proliferation and apoptosis in vascular endothelial cells
Modulation by leptin of proliferation and apoptosis in vascular endothelial cells
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DOI：
10.1038/sj.ijo.0801947
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发表时间：
2002-04-01
影响因子：
4.9
通讯作者：
Baumgartner-Parzer, SM
中科院分区：
文献类型：
--
作者：
Artwohl, M;Roden, M;Baumgartner-Parzer, SM
目的：血浆瘦素水平不仅与体脂含量有关，而且与高血压视网膜病变的程度有关。本研究的目的是进一步研究，是否瘦素的增殖，proanglogenic活动涉及到一个尚未发现的anti-apoptosis effect.RESULTS：瘦素（10-50 nmol/l）浓度依赖性地减少凋亡HUVECs（人脐静脉内皮细胞），HAVECs（人成人静脉内皮细胞）和HMEC（人微血管内皮细胞）的20%（P小于或等于0.05）。这些发现得到了细胞凋亡抑制因子bcl-2表达增加的支持（+55%，P
AIM: Plasma leptin concentrations not only correlate with body fat mass, but also with the degree of hypertensive retinopathy. The present study was designed to further examine, whether leptin's proliferative, proanglogenic activity relates to a yet uncovered anti-apoptotic effect.RESULTS: Leptin (10-50 nmol/l) concentration-dependently reduced apoptosis in HUVECs (human umbilical vein endothelial cells), HAVECs (human adult vein endothelial cells) and HMECs (human microvascular endothelial cells) by 20% (P less than or equal to 0.05). These findings were supported by increased expression of the apoptosis inhibitor bcl-2 (+55%, P