The comparative immunology of wild and laboratory mice, Mus musculus domesticus.
The comparative immunology of wild and laboratory mice, Mus musculus domesticus.
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DOI：
10.1038/ncomms14811
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发表时间：
2017-05-03
影响因子：
16.6
通讯作者：
Riley EM
中科院分区：
文献类型：
--
作者：
Abolins S;King EC;Lazarou L;Weldon L;Hughes L;Drescher P;Raynes JG;Hafalla JCR;Viney ME;Riley EM
实验室小鼠是免疫学的主力，被用作哺乳动物免疫功能的模型，但实验室小鼠的免疫反应在多大程度上反映了自由生活动物的免疫反应尚不清楚。在这里，我们综合表征了野生小鼠的血清学、细胞和功能免疫参数，并与实验室小鼠进行了比较，发现野生小鼠的细胞免疫系统相对而言处于高度激活(预置)状态。免疫参数和感染之间的关系表明，高水平的病原体暴露推动了这种激活。此外，野生小鼠有一群实验室小鼠没有的高度激活的髓系细胞。相比之下，在体外，野鼠细胞对病原体相关配体的细胞因子反应通常较低，这可能反映了在野外面对激烈的抗原挑战时保持免疫动态平衡的重要性。这些数据为验证(或不验证)实验室小鼠作为有用和相关的免疫模型系统提供了全面的基础。实验室小鼠是免疫学的基石，但它们代表野生小鼠的能力尚不清楚。在这里，作者比较和对比了野生捕获的小鼠和实验室(C57BL/6)小鼠的各种免疫参数，并确定了一种以前未知的野生小鼠特有的髓系细胞群。
The laboratory mouse is the workhorse of immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect those of free-living animals is unknown. Here we comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice, finding that wild mouse cellular immune systems are, comparatively, in a highly activated (primed) state. Associations between immune parameters and infection suggest that high level pathogen exposure drives this activation. Moreover, wild mice have a population of highly activated myeloid cells not present in laboratory mice. By contrast, in vitro cytokine responses to pathogen-associated ligands are generally lower in cells from wild mice, probably reflecting the importance of maintaining immune homeostasis in the face of intense antigenic challenge in the wild. These data provide a comprehensive basis for validating (or not) laboratory mice as a useful and relevant immunological model system. Laboratory mice are the cornerstone of immunology but how well they represent wild mice is not clear. Here the authors compare and contrast various immune parameters between wild-caught mice and laboratory (C57BL/6) mice and identify a previously unknown myeloid cell population specific to wild mice.