Changes in biochemical parameters related to atherosclerosis after Helicobacter pylori eradication
Changes in biochemical parameters related to atherosclerosis after Helicobacter pylori eradication
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DOI：
10.1111/j.1365-2036.2006.00026.x
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发表时间：
2006-12-01
影响因子：
7.6
通讯作者：
Goto, H.
中科院分区：
文献类型：
--
作者：
Ando, T.;Minami, M.;Goto, H.
目的探讨幽门螺杆菌(Hp)感染与血清动脉粥样硬化生化指标的关系。方法对189例Hp阳性消化性溃疡(十二指肠溃疡89例，胃溃疡70例)进行前瞻性研究，观察3年内与炎症和心血管事件相关的临床参数。结果根除成功137例(86%)，体重、体重指数(BMI)、甘油三酯(TG)逐年升高。血浆总胆固醇、白介素6、白介素8水平无明显变化，而高密度脂蛋白胆固醇水平显著升高，C反应蛋白、纤维蛋白原、低密度脂蛋白胆固醇水平下降。结论幽门螺杆菌感染可能通过加重或影响动脉粥样硬化的危险因素而参与心血管事件的发生。
BackgroundRecent evidence suggests that Helicobacter pylori infection is involved in the pathogenesis of extra-gastrointestinal diseases such as coronary heart disease.AimTo determine the association of H. pylori infection with biochemical parameters of atherosclerosis in the serum.MethodsOne hundred and fifty-nine patients with H. pylori-positive peptic ulcer (duodenal ulcer, n=89; gastric ulcer, n=70) receiving triple therapy were studied prospectively for up to 3 years for clinical parameters associated with inflammation and cardiovascular events. Blood was tested at the time of annual check-up.ResultsEradication was successful in 137 patients (86%), and body weight, body mass index (BMI) and TG levels increased gradually each year. No significant hanges were seen in plasma levels of total cholesterol, interleukin-6 or interleukin-8, whereas those of HDL-C increased significantly, and those of C-reactive protein, fibrinogen and LDL-C decreased.ConclusionThere is evidence for the possible implication of H. pylori infection in the etiology of cardiovascular events via its exacerbation of or influence on risk factors of atherogenesis.