Impact of Pupil Diameter on Axial Growth in Orthokeratology
Impact of Pupil Diameter on Axial Growth in Orthokeratology
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DOI：
10.1097/opx.0b013e31826c1831
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发表时间：
2012-11-01
影响因子：
1.4
通讯作者：
Chu, Renyuan
中科院分区：
文献类型：
--
作者：
Chen, Zhi;Niu, Lingling;Chu, Renyuan
目的.比较近视角膜塑形（OK）接触透镜和眼镜佩戴者的眼轴伸长，并探讨OK治疗后瞳孔直径对近视儿童眼轴生长的影响。方法。52名9 - 14岁的中国儿童入组本研究，27名为OK组，25名为单视眼镜片（SVL）组。每组受试者根据其基线暗视瞳孔直径进一步分为两个亚类。在基线和每6个月访视时测量轴长（AL），直至24个月。使用线性混合效应模型确定近视进展（AL较基线的变化）。在该模型中，重复访视被视为受试者内效应，治疗组和瞳孔大小被视为受试者间效应。分析治疗组 * 瞳孔大小的相互作用。分析两个透镜组24个月时眼轴生长与基线瞳孔面积之间的关系。OK组中的25例受试者和SVL组中的22例受试者完成了24个月研究。在整个观察的24个月期间，AL显著增加（F = 32.09，p < 0.001）。瞳孔大小显著影响轴向生长（F = 15.95，p < 0.001），并且不同治疗方式（OK与SVL）与瞳孔大小对轴向生长的影响相互作用（F = 24.66，p < 0.001）。更具体地说，在OK组中，高于平均瞳孔大小的受试者的轴向生长明显慢于低于平均瞳孔大小的受试者（F = 25.04，p < 0.001）。相反，瞳孔大小不影响SVL组的轴向生长（F = 0.46，p = 0.50）。在OK组中，基础暗视瞳孔面积与眼轴增长显著相关（r（2）= 0.405，p < 0.001），但在SVL组中不相关（r（2）= 0.171，p = 0.056）。大瞳孔直径有助于OK减缓近视眼轴向生长的效果。我们推测，这是因为周边视网膜的近视移位增强。（Optom维斯科学2012;89：1636-1640）
Purpose. To compare axial elongation between myopic orthokeratology (OK) contact lens and spectacle wearers, and to investigate the impact of pupil diameter on axial growth in myopic children after OK treatment.Methods. Fifty-two Chinese children aged 9 to 14 years were enrolled in this study, 27 for the OK group and 25 for the single vision spectacle lenses (SVL) group. Subjects in each group were further divided into two subcategories according to their baseline scotopic pupil diameters. Axial length (AL) was measured at baseline and at every 6-month visit through to 24 months. Linear mixed-effect model was used to determine myopia progression (AL changes from baseline). In this model, repeated visits were taken as within-subject effect, and treatment group as well as pupil size were taken as between-subject effects. The interaction of treatment group*pupil size was analyzed. Relationships between axial growth at 24 months and baseline pupil area were analyzed in both lens groups.Results. Twenty-five subjects in the OK group and 22 subjects in the SVL group completed the 24-month study. AL increased significantly throughout the observed 24-month period (F = 32.09, p < 0.001). Pupil size significantly affected axial growth (F = 15.95, p < 0.001) and different treatment modalities (OK vs. SVL) interacted with the effect of pupil size on axial growth (F = 24.66, p < 0.001). To be more specific, axial growth was significantly slower in subjects with above average pupil sizes than those with below average pupil sizes in the OK group (F = 25.04, p < 0.001). Contrarily, pupil size did not affect axial growth in the SVL group (F = 0.46, p = 0.50). Baseline scotopic pupil area was significantly correlated to axial growth in the OK group (r(2) = 0.405, p < 0.001) but not in the SVL group (r(2) = 0.171, p = 0.056).Conclusions. Large pupil diameters facilitate the effect of OK to slow axial growth in myopia. We speculate that this is because of enhancement of the myopic shift in the peripheral retina. (Optom Vis Sci 2012;89:1636-1640)