Leptin-Melanocortin pathway variants and gastric emptying in patients with obesity.
Leptin-Melanocortin pathway variants and gastric emptying in patients with obesity.
复制标题
瘦素-黑皮质素通路变异和肥胖患者的胃排空。
DOI：
10.1111/nmo.14764
复制
发表时间：
2024
影响因子：
3.5
通讯作者：
Acosta,Andres
中科院分区：
文献类型：
--
作者：
Cifuentes,Lizeth;Ghusn,Wissam;Campos,Alejandro;Bublitz,JoshuaT;Hurtado,MariaDaniela;Olson,Janet;Acosta,Andres
背景胃排空加速（GE）是肥胖的一个特征.下丘脑瘦素-黑皮质素4受体（Leptin‐ MC 4 R）通路的突变与肥胖相关。我们试图调查瘦素-MC 4 R通路变异体和GE在patients with obesity.MethodsThis是一项横断面研究的患者有严重肥胖的历史，基因分型，并完成了GE测试，通过荧光造影。我们使用ANCOVA以体重和性别作为协变量评估了两组之间在2和4 h时的GE百分比（GE %）。我们根据所识别的变异的位置将患者细分为携带者（即，Leptin-MC 4 R途径的上游或下游），并使用ANOVA将其与非携带者进行比较。结果以平均值和标准差（± SD）表示。关键结果共纳入95例患者; 9例携带者（67%女性; 39.78 ± 12.33岁; BMI：49.14 ± 12.96 kg/m2）和86例非携带者（87%女性; 49.98 ± 13.74岁; BMI：40.75 ± 6.29 kg/m2）。在2和4小时，携带者与非携带者相比，GE延迟（分别为p= 0.03和p = 0.005）。在携带者中，当比较上游携带者与下游携带者与非携带者的位置时，在2 h和4 h组间GE存在显著差异（分别为p= 0.02和p = 0.01）。这些发现指出了Leptin‐ MC 4 R通路与胃运动之间的重要关系。
BackgroundAccelerated gastric emptying (GE) is a trait seen in obesity. Mutations in the hypothalamic leptin‐melanocortin 4 receptor (Leptin‐MC4R) pathway have been associated with obesity. We sought to investigate the association of leptin‐MC4R pathway variants and GE in patients with obesity.MethodsThis is a cross‐sectional study of patients with a history of severe obesity that were genotyped and completed a GE test by scintigraphy. We evaluated the percentage of GE (GE %) at 2 and 4 h between both groups using ANCOVA with weight and sex as covariates. We subdivide patients into carriers based on the location of the identified variants (i.e., upstream or downstream of the Leptin‐MC4R pathway) and compared them with noncarriers using ANOVA. Results are presented as mean and standard deviation (± SD).Key ResultsA total of 95 patients; nine carriers (67% females; 39.78 ± 12.33 years; BMI: 49.14 ± 12.96 kg/m2) and 86 noncarriers (87% female; 49.98 ± 13.74 years; BMI: 40.75 ± 6.29 kg/m2) were included. At 2 and 4 h, carriers had a delayed GE when compared noncarriers (p= 0.03 andp= 0.005, respectively). In carriers, when compared upstream carriers vs. downstream carriers vs. noncarriers by location there was a significant difference in GE among groups at 2 h and at 4 h (p= 0.02 andp= 0.01, respectively).Conclusions & InferencesCarriers of heterozygous variants in the Leptin‐MC4R pathway had a delayed GE compared to noncarriers. These findings point the important relationship between the Leptin‐MC4R pathway and gastric motility.