Effects of calcium channel blockers on pentylenetetrazol drug discrimination in rats.
Effects of calcium channel blockers on pentylenetetrazol drug discrimination in rats.
复制标题
钙通道阻滞剂对大鼠戊四唑药物辨别的影响。
DOI：
10.1016/s0741-8329(01)00123-9
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Lal,H
中科院分区：
文献类型：
--
作者：
Gatch,MB;Wallis,CJ;Lal,H
研究了二氢吡啶类L型钙通道阻滞剂尼群地平和尼莫地平对戊四氮（PTZ）药物辨别的影响。训练雄性Long-Evans大鼠辨别PTZ（16 mg/kg，i. p.）来自盐水。尼群地平（5.0-25 mg/kg，i. p.）和尼莫地平（5.0-25 mg/kg，i. p.）部分替代PTZ辨别刺激。然而，用尼群地平（25 mg/kg，i. p.）或尼莫地平（25 mg/kg，i. p.）PTZ剂量效应函数无变化。大鼠给予营养均衡的含6.5%乙醇的流质饮食10天。大鼠在戒断过程中选择PTZ药物杆。尼群地平（1.25-5.0 mg/kg，i. p.，b.i.d.）乙醇不能剂量依赖性地减少PTZ-杠杆反应，但它确实逆转了戒断症状。急性给药尼群地平（5、10和20 mg/kg，i. p.）产生了显着的抑制杠杆反应，但它未能显着降低水平的PTZ杠杆反应。虽然钙通道阻滞剂减少了乙醇戒断症状，但它们也显著降低了行为率，对乙醇戒断诱导的焦虑样行为没有明显影响。
The effects of the dihydropyridine L-type calcium channel blockers nitrendipine and nimodipine on the pentylenetetrazol (PTZ) drug discrimination, an operant model of anxiety, were investigated. Male Long–Evans rats were trained to discriminate PTZ (16 mg/kg, i.p.) from saline. Both nitrendipine (5.0–25 mg/kg, i.p.) and nimodipine (5.0–25 mg/kg, i.p.) partially substituted for the PTZ discriminative stimulus. However, pretreatment with nitrendipine (25 mg/kg, i.p.) or nimodipine (25 mg/kg, i.p.) produced no change in the PTZ dose-effect function. Rats were given a nutritionally balanced liquid diet containing 6.5% ethanol for 10 days. Rats selected the PTZ drug lever during withdrawal. Subchronic coadministration of nitrendipine (1.25–5.0 mg/kg, i.p., b.i.d.) with ethanol failed to dose-dependently reduce PTZ-lever responding, but it did reverse withdrawal signs. Acute administration of nitrendipine (5, 10, and 20 mg/kg, i.p.) produced marked suppression of lever responding, but it failed to significantly reduce levels of PTZ-lever responding. Although calcium channel blockers reduce signs of ethanol withdrawal, they also markedly reduce rates of behavior and produce no clear effects on anxiety-like behaviors induced by ethanol withdrawal.