Clomipramine Treatment of Hyperventilation Syndrome
Clomipramine Treatment of Hyperventilation Syndrome
复制标题
氯米帕明治疗过度换气综合征
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
H. Folgering
中科院分区：
文献类型：
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作者：
M. Hoes;P. Colla;H. Folgering
6例患者出现过度换气综合征3.4+/-1.2年。他们在静息状态下的PaCO2降低，二氧化碳反应曲线异常。在整个期间，他们接受了抗焦虑药物的治疗，但没有成功，在过去的一到两年里，他们也接受了行为治疗，但都没有成功。两种治疗均停止，患者接受氯丙咪嗪25 mg，tid。已经9个月了。服用氯丙咪嗪一个月后，他们的焦虑和过度换气发作减轻，两个月后，他们对发作的恐惧和恐惧症消退。氯丙咪嗪治疗开始18个月后，他们在没有药物治疗的情况下感觉良好。本文还讨论了氯丙咪嗪通过中枢5-羟色胺能机制治疗过度换气综合征的可能机制。
Six patients suffered from a hyperventilation syndrome for 3.4 +/- 1.2 years. They had a lowered PAco2 at rest and an abnormal CO2 response curve. During the entire period they had received unsuccessful treatment with anxiolytics, and had also undergone behaviour therapy for the last 1 -- 2 years without success. Both treatments were discontinued and the patients were placed on clomipramine, 25 mg t.i.d. for 9 months. Their anxiety and hyperventilation attacks diminished after one month of clomipramine, and their fear of attacks an their phobias subsided after two months. Eighteen months after clomipramine therapy had been initiated, they were feeling well without medication. The possible mode of action of clomipramine on the hyperventilation syndrome via central serotonergic mechanism is discussed.