Dehydrogenases/Reductases for the Synthesis of Chiral Pharmaceutical Intermediates
Dehydrogenases/Reductases for the Synthesis of Chiral Pharmaceutical Intermediates
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DOI：
10.2174/138527210791616795
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发表时间：
2010-08-01
影响因子：
2.6
通讯作者：
Chen, Yijun
中科院分区：
文献类型：
--
作者：
Huang, Yan;Liu, Nan;Chen, Yijun
手性药物在制药工业中的日益增长的趋势极大地促进了许多生物催化与化学方法相结合的途径的发展。由于手性醇是合成手性药物的重要中间体和前体，因此，酶和还原酶被广泛用于从酮底物合成手性化合物，具有高的区域和立体选择性。本文综述了生物酶和还原酶催化合成抗抑郁药、抗焦虑药、抗哮喘药、抗高血压药、降胆固醇药、NK 1拮抗剂、ACE抑制剂和β-内酰胺酶抑制剂等药物的手性中间体的研究进展。
The increasing trend of chiral drugs in the pharmaceutical industry has promoted greatly on the development of numerous biocatalytic routes in combination with chemical methods. Because the resulting chiral alcohols are particularly valuable intermediates and precursors for the synthesis of chiral drugs, dehydrogenases and reductases have been extensively used in the synthesis of chiral compounds from ketone substrates with high regio- and stereo-selectivities. In this review, biocatalytic processes carried out by dehydrogenases and reductases are described for the synthesis of chiral intermediates for a wide variety of pharmaceuticals, including antidepressants, anti-anxieties, anti-asthmatics, anti-hypertensives, cholesterol-lowering agents, NK1 antagonists, ACE inhibitors and beta-Lactamase inhibitors.