Internal Diversification of Mitochondrial Haplogroup R0a Reveals Post-Last Glacial Maximum Demographic Expansions in South Arabia
Internal Diversification of Mitochondrial Haplogroup R0a Reveals Post-Last Glacial Maximum Demographic Expansions in South Arabia
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DOI：
10.1093/molbev/msq178
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发表时间：
2011-01-01
影响因子：
10.7
通讯作者：
Pereira, Luisa
中科院分区：
文献类型：
--
作者：
Cerny, Viktor;Mulligan, Connie J.;Pereira, Luisa
与6万至8万年前的现代人类通过南部迁徙路线类似，第一次成功地离开非洲的现代人的广泛兴趣盖过了对南阿拉伯史前后期阶段的研究。在这项工作中，我们指出，过去20000年的末次冰期后最大时期是该地区现存遗传组成和种群结构形成的重要时期，在这段时期内，气候条件变得更加适宜。这一结论得到了单倍群R0a--阿拉伯最常见和最广泛的单倍群--89个完整线粒体基因组(此处新公布71个)的高度分辨的系统发育树中所显示的内部多样性的支持。此外，在居住在阿拉伯半岛南部的Soqotri人和Mahri人等非阿拉伯语民族中发现了两个地理上特定的支系(R0a1a1a和R0a2f1)，独立的考古研究确定了那里过去的避难所。对这些血统最新共同祖先的时间估计与公元前六千年半岛上航海活动的最早考古证据相符。
Widespread interest in the first successful Out of Africa dispersal of modern humans similar to 60-80 thousand years ago via a southern migration route has overshadowed the study of later periods of South Arabian prehistory. In this work, we show that the post-Last Glacial Maximum period of the past 20,000 years, during which climatic conditions were becoming more hospitable, has been a significant time in the formation of the extant genetic composition and population structure of this region. This conclusion is supported by the internal diversification displayed in the highly resolved phylogenetic tree of 89 whole mitochondrial genomes (71 being newly presented here) for haplogroup R0a-the most frequent and widespread haplogroup in Arabia. Additionally, two geographically specific clades (R0a1a1a and R0a2f1) have been identified in non-Arabic speaking peoples such as the Soqotri and Mahri living in the southern part of the Arabian Peninsula where a past refugium was identified by independent archaeological studies. Estimates of time to the most recent common ancestor of these lineages match the earliest archaeological evidence for seafaring activity in the peninsula in the sixth millennium BC.