Polydopamine-based nanomaterials and their potentials in advanced drug delivery and therapy
Polydopamine-based nanomaterials and their potentials in advanced drug delivery and therapy
复制标题
基于聚多巴胺的纳米材料及其在先进药物输送和治疗中的潜力
DOI：
10.1016/j.colsurfb.2020.111502
复制
发表时间：
2021-03-01
影响因子：
5.8
通讯作者：
Peng, Qiang
中科院分区：
文献类型：
--
作者：
Li, Hanmei;Yin, Dan;Peng, Qiang
聚多巴胺（polydopamine，PDA）由于其独特的理化性质，如高的光热传递效率、良好的药物结合能力、多样的粘附能力、敏感的pH响应性以及良好的生物相容性和生物降解性，在生物医学领域显示出巨大的应用潜力。这些性质赋予了基于PDA的纳米颗粒作为先进药物递送的药物载体或作为光热治疗、成像和生物传感的生物活性剂的潜力。本文综述了PDA及其聚合机制，以及基于PDA的纳米系统在治疗癌症、糖尿病、炎症、细菌感染和帕金森病等多种疾病方面的潜力。此外，还讨论了PDA在生物医学应用中的问题。
Polydopamine (PDA) has shown great potentials in biomedical fields due largely to its unique physicochemical properties, including high photothermal transfer efficiency, excellent drug binding capacity, versatile adhesion ability, sensitive pH responsibility and great biocompatibility and biodegradability. These properties confer PDAbased nanoparticles the potentials either as the drug carriers for advanced drug delivery or as the bioactive agents for photothermal therapy, imaging and biosensing. This review aims to provide a comprehensive understanding of PDA, its polymerization mechanisms and the potentials of PDA-based nano-systems in treating various diseases, including cancer, diabetes, inflammation, bacterial infection and Parkinson's disease. In addition, the concerns of PDA in biomedical use are also discussed.