CD13 and TCR clone:: Markers of early mycosis fungoides
CD13 and TCR clone:: Markers of early mycosis fungoides
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DOI：
10.2340/00015555-0197
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发表时间：
2007-01-01
影响因子：
3.6
通讯作者：
Dreno, Brigitte
中科院分区：
文献类型：
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作者：
Bernier, Claire;Nguyen, Jean-Michel;Dreno, Brigitte
早期蕈样肉芽肿（MF）和类银屑病之间的鉴别诊断往往是困难的，在临床和组织学水平。这项研究的目的是探索可以帮助这个过程的标记。共有88名患者被纳入2类：大斑块状副银屑病和趾状副银屑病。对每例患者进行组织学检查，并分析了皮肤T淋巴瘤（CTCL）（但不是炎性病变）中缺乏的抗原My7（CD13）的表达和T细胞受体基因的重排。在23.5%的大斑块型副银屑病病例和15%的指状副银屑病病例中观察到向表皮CTCL的组织学方面。My7抗原的消失在2种形式的类银屑病中观察到，当有CTCL组织学时更常见。在10.3%的大斑块型副韧带病例中观察到皮肤克隆，但在指状副韧带病例中未观察到皮肤克隆。对于3名患者来说，皮肤克隆和My7的消失与非特异性组织学相关。综合这些组织学、免疫学和分子生物学资料，My7抗原结合T细胞克隆可能有助于皮肤科医生确诊早期ME。此外，进一步的研究将确定CD 13是否是一个早期预后指标。
Making a differential diagnosis between early mycosis fungoides (MF) and parapsoriasis is often difficult at the clinical and histological level. The aim of this study was to explore markers that could help in this process. A total of 88 patients were included in 2 categories: large plaque parapsoriasis and digitiform parapsoriasis. A histological examination was performed for each patient, and expression of the antigen My7 (CD13), which is lacking in cutaneous T-lymphomas (CTCL) (but not in inflammatory lesions) and rearrangement of the T-cell receptor gene were analysed. A histological aspect of epidermotropic CTCL was observed in 23.5% of cases of large plaque parapsoriasis and 15% of cases of digitiform parapsoriasis. A disappearance of My7 antigen was noted in the 2 forms of parapsoriasis, more frequently when there was CTCL histology. A cutaneous clone was observed in 10.3% of cases of large plaque parapsoriasis, but not of digitiform parapsoriasis. For 3 patients, a cutaneous clone and a disappearance of My7 were associated with a non-specific histology. Considering these histological, immunological and molecular biological data, it appears that My7 antigen combined with T-cell clone may help the dermatologist to confirm the diagnosis of early ME Moreover, further studies will determine whether CD13 is an early prognostic marker of evolution of a parapsoriasis to ME Finally, these results demonstrate that digitiform parapsoriasis can be an early stage of MF.