Regional brain atrophy in cognitively intact adults with a single APOE ε4 allele
Regional brain atrophy in cognitively intact adults with a single APOE ε4 allele
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DOI：
10.1212/01.wnl.0000238079.00472.3a
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发表时间：
2006-10-10
期刊：
影响因子：
9.9
通讯作者：
Rhodes, C. H.
中科院分区：
文献类型：
--
作者：
Wishart, H. A.;Saykin, A. J.;Rhodes, C. H.
目的：确定具有 APOE epsilon 3/epsilon 4 基因型的认知完整的成年人与 epsilon 3 等位基因纯合的成年人相比，在基于体素的形态测量 (VBM) 上是否表现出灰质密度降低。方法：参与者是健康、认知能力完整、惯用右手的成年人，年龄在 19 岁至 80 岁之间，完成了基因分型、神经心理学测试和 MRI。 49 名参与者具有 epsilon 3/epsilon 3 基因型，27 名参与者具有 epsilon 3/epsilon 4 基因型。使用统计参数映射包中实现的一般线性模型分析灰质数据，并根据年龄和性别进行调整。结果：epsilon 3/epsilon 4 参与者在右侧内侧颞叶和双侧额颞区以及其他区域的灰质密度低于 epsilon 3/epsilon 3 参与者。没有任何区域 epsilon 3/epsilon 4 参与者表现出比 epsilon 3/epsilon 3 参与者更高的灰质密度。结论：在具有单个 APOE epsilon 4 等位基因拷贝的认知完整的成年人中，可以检测到局部灰质密度降低。
Objective: To determine whether cognitively intact adults with the APOE epsilon 3/epsilon 4 genotype show reduced gray matter density on voxel-based morphometry (VBM) vs those homozygous for the epsilon 3 allele. Methods: Participants were healthy, cognitively intact, right-handed adults, age 19 to 80, who completed genotyping, neuropsychological testing, and MRI. Forty-nine participants had the epsilon 3/epsilon 3 genotype and 27 had the epsilon 3/epsilon 4 genotype. Gray matter data were analyzed using the general linear model as implemented in the Statistical Parametric Mapping package, adjusting for age and sex. Results: The epsilon 3/epsilon 4 participants showed lower gray matter density than the epsilon 3/epsilon 3 participants in right medial temporal and bilateral frontotemporal regions as well as other areas. There were no regions in which epsilon 3/epsilon 4 participants showed higher gray matter density than epsilon 3/epsilon 3 participants. Conclusions: Regionally reduced gray matter density is detectable in cognitively intact adults with a single copy of the APOE epsilon 4 allele.