Nickel-Catalyzed Reductive Conjugate Addition of Primary Alkyl Bromides to Enones To Form Silyl Enol Ethers.
Nickel-Catalyzed Reductive Conjugate Addition of Primary Alkyl Bromides to Enones To Form Silyl Enol Ethers.
复制标题
镍催化的还原偶联物添加原代烷基溴化物以形成甲硅烷基烯醇醚。
DOI：
10.1021/acs.orglett.6b03509
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发表时间：
2017-01-20
期刊：
影响因子：
5.2
通讯作者：
Weix DJ
中科院分区：
文献类型：
--
作者：
Huihui KM;Shrestha R;Weix DJ
Conjugate addition of organometallic reagents to enones to form silyl enol ether products is a versatile method to difunctionalize activated olefins, but the organometallic reagents required can be limiting. The reductive cross-electrophile coupling of unhindered primary alkyl bromides with enones and chlorosilanes to form silyl enol ether products is catalyzed by a nickel-complexed ortho-brominated terpyridine ligand. The conditions are compatible with a variety of cyclic/acyclic enones and functional groups.
