Pilocarpine toxicity. Effects on the rabbit corneal endothelium.
Pilocarpine toxicity. Effects on the rabbit corneal endothelium.
复制标题
毛果芸香碱毒性。
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
W. Coles
中科院分区：
文献类型：
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作者：
W. Coles
采用离体灌流法、光学显微镜、透射电镜等方法研究了毛果芸香碱对健康兔角膜内皮细胞的影响。毛果芸香碱对内皮细胞的毒性与剂量有关。摄影显示暴露于毛果芸香碱的细胞收缩。最显著的超微结构变化是核异染色质边集和胞质空泡化。
The effects of pilocarpine on the healthy rabbit corneal endothelium were studied by in vitro perfusion, photography, and electron microscopy. The toxicity of endothelial cells to pilocarpine was doserelated. Photography showed shrinkage of cells exposed to pilocarpine. The most striking ultrastructure changes were margination of nuclear heterochromatin and cytoplasmic vacuolation.