Compromised decision-making and increased gambling proneness following dietary serotonin depletion in rats
Compromised decision-making and increased gambling proneness following dietary serotonin depletion in rats
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DOI：
10.1016/j.neuropharm.2011.11.002
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发表时间：
2012-03-01
影响因子：
4.7
通讯作者：
Adriani, W.
中科院分区：
文献类型：
--
作者：
Koot, S.;Zoratto, F.;Adriani, W.
心理遗传学研究揭示了大脑5-羟色胺系统在赌博倾向和决策失误中的作用。我们评估了操纵大鼠大脑5-羟色胺水平是否会影响决策和赌博倾向的操作性任务的表现。将雄性Wistar大鼠暴露于L-色氨酸（TRP）缺乏饲料（0.0 g/kg; T-组）或对照含L-色氨酸的饲料（2.8 g/kg; T+组）。同样的大鼠在啮齿动物爱荷华州赌博任务（rIGT）中使用家庭笼操作面板测试决策性能，随后在概率传递任务（rPDT）中使用经典Skinnerboxes测试赌博倾向。在处死时，用HPLC分析评价单胺和代谢物，证实了T大鼠前额叶皮层中的5-羟色胺合成急剧减少，以及多巴胺周转率改变。正如预期的那样，对照组大鼠（T+）在rIGT中逐渐选择了具有最佳长期回报的选项，并且在rPDT中也从“大&幸运链接”（LLL）转移到“小&确定”（SS）。相反，耗竭动物（T）在rIGT中表现出较弱的性能改善，并在rPDT中保持对LLL抑制剂的次优吸引力。比较两个测试中的个体表现，我们发现对照组（T+）中的两个任务之间存在显著相关性，但在耗竭组（T）大鼠中不存在相关性。目前的研究表明，（1）大脑5-HT耗竭导致决策能力低下和赌博倾向;（2）这两个特征之间的关系，在对照组中显示，在5-HT耗竭大鼠被破坏。数据进行了讨论，在认知和动机/情感过程中所涉及的前脑回路内的变化。(c)2011爱思唯尔有限公司版权所有。
Psycho-genetic studies have revealed a role for the brain serotonin system in gambling proneness and poor decision-making. We assessed whether manipulation of brain serotonin levels in rats affected performance in operant-based tasks for decision-making and gambling proneness. Male Wistar rats were exposed to an L-tryptophan (TRP) deficient diet (0.0 g/kg; T- group) or to a control, L-tryptophan containing diet (2.8 g/kg; T+ group). The same rats were tested for decision-making performance in the rodent Iowa Gambling Task (rIGT) using home-cage operant panels, and subsequently for gambling proneness in a Probabilistic Delivery Task (rPDT) using classic Skinnerboxes. At sacrifice, monoamines and metabolites were evaluated with HPLC analysis, confirming a drastically reduced serotonin synthesis, as well as altered dopamine turnover in the prefrontal cortex of T rats. As expected, control rats (T+) progressively chose the option with the best long-term payoff in the rIGT, and also shifted from "Large & Luck-Linked" (LLL) to "Small & Sure" (SS) reinforcers in the rPDT. In contrast, depleted animals (T) exhibited a weaker improvement of performance in the rIGT and maintained a sub-optimal attraction for LLL reinforcer in the rPDT. Comparing individual performances in both tests, we found a significant correlation between the two tasks in control (T+) but not in depleted (T) rats. The present study revealed that (1) brain 5-HT depletion leads to poor decision-making and to gambling proneness; (2) the relationship between these two traits, shown in the control group, was disrupted in 5-HT depleted rats. The data are discussed in terms of changes within forebrain loops involved in cognitive and motivational/affective processes. (c) 2011 Elsevier Ltd. All rights reserved.